Kuangyu Yen is a molecular biologist studying transcriptional regulation and chromatin control of gene expression. Her group combines bioinformatics, stem-cell differentiation, CRISPR/Cas9 perturbation, and biochemical reconstitution to investigate endothelial-to-hematopoietic transition and cell-fate change in disease. Her work has appeared in Cell, Nature, and Nature Communications. He received the Thousand Youth Talents Award and NSFC Outstanding Youth Award and serves on the Editorial Board Member of Communications Biology.
PhD, Molecular Biology, The University of Manchester, UK, 2001–2005
MRes, Molecular Biology, The University of Manchester, UK, 2000-2001
Bachelor of Science, Horticulture, Molecular Biology Unit, National Taiwan University, China, 1994-1998
PI, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 2022–
Professor, Southern Medical University, 2014-2022
Research Assistant Professor, Pennsylvania State University, 2012-2014
Postdoctoral Fellow, Pennsylvania State University, 2008-2012
Postdoctoral Fellow, University of Washington, 2005-2007
Research Assistant, National Taiwan University, 1998-2000
PRINCIPAL HONORS, AWARDS:
2016-2018 Thousand Youth Talents Award, ODCPC, China
2016-2018 Outstanding Youth Award, National Natural Science Foundation of China
MAJOR NATIONAL LEADERSHIP POSITIONS, SOCIETIES AND BOARDS:
2024-present Internal Editorial Board Member, Communications Biology
2016-2022 Member, BJRST Committee Panel, BJRST, Malaysia
SELECTED PUBLICATIONS:
* co-first author; # co-corresponding author
1.Liu Yang*, Shan Liu*, Ting Lu*, Shaokang Mo, Bin Qi, Kuangyu Yen. (2026) chromIDEAS reveals epigenetic dynamics via multi-dimensional clustering of chromatin states. Nucleic Acids Research. DOI: 10.1093/nar/gkag176.
2.Jianyu Yang, Kuangyu Yen#, Shaun Mahony#. (2024) Size-based expectation maximization for characterizing nucleosome positions and subtypes. Genome Research. DOI: 10.1101/gr.279138.124.
3.Shaokang Mo*, Kengyuan Qu*, Junfeng Huang*,#, Qiwei Li, Wenqing Zhang, Kuangyu Yen#. (2023) Cross-species transcriptomics reveals bifurcation point during the arterial-to-hemogenic transition. Communications Biology. 6(1):827.
4.Wang Yajie*, Lu Ting*, Sun Guohuan, Zheng Yawei, Yang Shangda, Zhang Hongyan, Hao Sha, Liu Yanfeng, Ma Shihui, Zhang Houyu, Ru Yongxin, Gao Shaorong, Yen Kuangyu#, Cheng Hui#, Cheng Tao#. (2019) Targeting of apoptosis gene loci by reprogramming factors leads to selective eradication of leukemia cells. Nature Communications. 10(1).
5.de Dieuleveult M*, Yen K*#, Hmitou I*, Depaux A*, Boussouar F, Dargham DB, Jounier S, Humbertclaude H, Ribierre F, Baulard C, Farrell NP, Park B, Keime C, Carriere L, Merlivet S, Gut M, Gut I, Werner M, Deleuze JF, Olaso R, Aude JC, Chantalat S, Pugh BF, Gerard M. (2016) Genome-wide nucleosome specificity and function of chromatin remodellers in ES cells. Nature. 530(7588):113-116.
6.Yen K, Vinayachandran V, Pugh BF. (2013) Genome-wide structural integration of SWR-C and INO80 chromatin remodelers at +1 nucleosomes. Cell. 154(6):1246-1256.
7.Yen K, Vinayachandran V, Batta K, Koerber RT, Pugh BF. (2012) Genome-wide nucleosome specificity and directionality of chromatin remodelers. Cell. 149(7):1461-1473.