Dr. Hong Wang is a principal investigator at the Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College. His research focuses on the development of advanced mass spectrometry-based proteomics technologies and integrative multi-omics analytical frameworks. By leveraging proteomics-centered multi-omics profiling and computational modeling, his work aims to elucidate the molecular mechanisms underlying blood diseases and to identify novel diagnostic biomarkers and therapeutic targets. Dr. Wang has published in high profile journals, including Nature Communications (2019, 2025), Immunity (2023), PNAS (2023), Genome Biology (2022), Cancer Cell (2018), and Interdisciplinary Medicine (2025), among others. His research was recognized as one of the Top 10 Scientific Advances in Hematology in China (2023) and selected as a Proteomics Highlight of the Year by the Human Proteome Organization (HUPO). He currently serves as Co-Chair of the HUPO Cancer Initiative and Secretary-General of the Translational Medicine Working Committee of the Chinese Physiological Society, contributing actively to international collaborations and the advancement of translational biomedical research.

PhD, Biomedical Sciences, University of Tennessee Health Science Center / St Jude Children's Research Hospital, Memphis, USA, 2011-2017

Bachelor of Medicine, Laboratory Medicine, Southwest Medical University, Sichuan, China, 2006-2011

Founding director, Center for Advanced Technologies (CAT), Haihe Laboratory of Cell Ecosystem, Tianjin, China, 2022-

Principal investigator of Medicine and Stem Cell Biology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China, 2021-

Senior Proteomics Scientist, St Jude Children's Research Hospital, Memphis, USA, 2017-2021

Postdoc, Structural Biology, St Jude Children's Research Hospital, Memphis, USA, 2017-2017

PRINCIPAL HONORS, AWARDS:

2023    HUPO Proteomics Highlight of the Year Awards

SELECTED PUBLICATIONS:

1. Dandan Yang#, Tingting Zhang#, Yang Yang#, Dong Zhang, Zhiwei Zhou, Ning Wang, Jinting Fan, Chenghua Xu, Youyang Fang, Lichun Kang, Mingming Niu, Chunliang Li, Long Shen∗, Hong Wang∗. Integration of CRISPR-Cas9 screens and multi-omics profiling reveals chromodomain helicase DNA binding protein 7-angiopoietin-1 as a novel multidrug resistance axis in acute myeloid leukemia. Interdisciplinary Medicine. 2025. e70053

2. Mingming Niu#, Dong Zhang#, Zhiwei Zhou#, Jiaqi Zhang#, Rong Zhang, Long Shen, Hong Wang∗. CAT-APP: Contamination Analysis and Tempering—An Automated Online Platform for Plasma Proteomics with Data Rescuing Capabilities. bioRxiv. 2025.07. 08.663798

3. Wenchang Qian#, Penglei Jiang#, Mingming Niu#, Yujuan Fu#, Deyu Huang, Dong Zhang, Ying Liang, Qiwei Wang, Yingli Han, Xin Zeng, Yixin Shi, Lingli Jiang, Zebin Yu, Jinxin Li, Huan Lu, Hong Wang∗, Baohui Chen∗, Pengxu Qian∗. Selective identification of epigenetic regulators at methylated genomic sites by SelectID. Nature Communications. 2025.16(1): 3709

4. Mingming Niu#, Ning Wang#, Dandan Yang#, Lixia Fu#, Yang Yang, Long Shen, Hong Wang∗, Xianfeng Shao∗. Multi-omics integration reveals immune hallmarks and biomarkers associated with FLT3 inhibitor sensitivity in FLT3-mutated AML. Blood Science.7(2):p e00227, June 2025

5. Hong Wang∗, Tao Cheng∗. Towards a blood ecosystem approach to dissect systemic diseases. Sci China Life Sci. 2024. 67 (7), 1528-1531

6. Hong Wang∗#, Cuicui Liu#, Xiaowei Xie#, Mingming Niu#, Yingrui Wang#, Xuelian Cheng#, Biao Zhang#, Dong Zhang, Mengyao Liu, Rui Sun, Yezi Ma, Shihui Ma, Huijun Wang, Guoqing Zhu, Yang Lu, Baiming Huang, Pei Su, Xiaoyuan Chen, Jingjing Zhao, Hongtao Wang, Long Shen, Lixia Fu, Qianqian Huang, Yang Yang, He Wang, Chunlong Wu, Weigang Ge, Chen Chen, Qianyu Huo, Qingping Wang, Ying Wang, Li Geng, Yan Xie, Yi Xie, Lijun Liu, Jianwei Qi, Huaiyong Chen, Junping Wu, Erlie Jiang, Wentiao Jiang, Ximo Wang∗, Zhongyang Shen∗, Tiannan Guo∗, Jiaxi Zhou∗, Ping Zhu∗, Tao Cheng∗. Multi-omics blood atlas reveals unique features of immune and platelet responses to SARS-CoV-2 Omicron breakthrough infection. Immunity. 2023.56(6): 1410-1428

7. Shaela Wright#, Jianzhong Hu#, Hong Wang#, Judith Hyle, Yang Zhang, Guoqing Du, Marina Y Konopleva, Steven M Kornblau, Mohamed Nadhir Djekidel, Wojciech Rosikiewicz, Beisi Xu, Rui Lu, Jun J Yang∗, Chunliang Li∗. Interrogating bromodomain inhibitor resistance in KMT2A-rearranged leukemia through combinatorial CRISPR screens. Proc Natl Acad Sci USA. 2023. Apr 18;120(16):e2220134120

8. Beisi Xu#, Hong Wang#, Shaela Wright, Judith Hyle, Yang Zhang, Ying Shao, Mingming Niu, Yiping Fan, Wojciech Rosikiewicz, Mohamed Nadhir Djekidel, Junmin Peng, Rui Lu, Chunliang Li∗. Acute depletion of CTCF rewires genome-wide chromatin accessibility. Genome Biology. 2021.22 (1):1-25

9. Hong Wang∗#, Kaushik Kumar Dey#, Ping-Chung Chen, Yuxin Li, Mingming Niu, Ji-Hoon Cho, Xusheng Wang, Bing Bai, Yun Jiao, Surendhar Reddy Chepyala, Vahram Haroutunian, Bin Zhang, Thomas G. Beach and Junmin Peng∗. Integrated analysis of ultra-deep proteomes in cortex, cerebrospinal fluid and serum reveals a mitochondrial signature in Alzheimer’s disease. Molecular Neurodegeneration. 2020.15(1):43

10. Hong Wang#, Alexander K Diaz, Timothy I Shaw, Yuxin Li, Mingming Niu, Ji-Hoon Cho, Barbara S Paugh, Yang Zhang, Jeffrey Sifford, Bing Bai, Zhiping Wu, Haiyan Tan, Suiping Zhou, Laura D Hover, Heather S Tillman, Abbas Shirinifard, Suresh Thiagarajan, Andras Sablauer, Vishwajeeth Pagala, Anthony A High, Xusheng Wang, Chunliang Li, Suzanne J Baker∗, Junmin Peng∗. Deep multi-omics profiling of brain tumors identifies signaling networks downstream of cancer driver genes. Nature Communications. 2019. 10(1):3718

11. Kaushik Kumar Dey#, Hong Wang#, Mingming Niu, Bing Bai, Xusheng Wang, Yuxin Li, Ji-Hoon Cho, Haiyan Tan, Ashutosh Mishra, Anthony A High, Ping-Chung Chen, Zhiping Wu, Thomas G Beach, Junmin Peng∗. Deep undepleted human serum proteome profiling toward biomarker discovery for Alzheimer’s disease. Clinical Proteomics. 2019.16:16

12. Elizabeth Stewart#, Justina McEvoy#, Hong Wang#, Xiang Chen#, Victoria Honnell, Monica Ocarz, Brittney Gordon, Jason Dapper, Kaley Blankenship, Yanling Yang, Yuxin Li, Timothy I Shaw, Ji-Hoon Cho, Xusheng Wang, Beisi Xu, Pankaj Gupta, Yiping Fan, Yu Liu, Michael Rusch, Lyra Griffiths, Jongrye Jeon, Burgess B Freeman III, Michael R Clay, Alberto Pappo, John Easton, Sheila Shurtleff, Anang Shelat, Xin Zhou, Kristy Boggs, Heather Mulder, Donald Yergeau, Armita Bahrami, Elaine R Mardis, Richard K Wilson, Jinghui Zhang, Junmin Peng, James R Downing, Michael A Dyer∗, St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project. Identification of Therapeutic Targets in Rhabdomyosarcoma Through Integrated Genomic, Epigenomic, and Proteomic Analyses. Cancer Cell. 2018. 34(3):411-426.e19