Served as PI for over 10 national-level research grants. Research fields: hematopoietic stem cell biology and pathogenesis of leukemia. Seek to elucidate mechanisms underlying the regulation of normal and malignant hematopoiesis and develop targeted therapeutic approaches.
Ph.D, Cell Biology, Peking Union Medical College, Beijing, China, 2003-2005
MS, Cell Biology, Peking Union Medical College, Beijing, China, 1997-1999
BS, Microbiology, Nan Kai University, Tianjin, China, 1985-1989
Professor, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 2007-
Associate professor, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 2000-2005
Assistant professor, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 1995-2000
Junior Research Fellow, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 1989-1995
PRINCIPAL HONORS, AWARDS:
2006 Second Prize of Tianjin Natural Science Award
2002 Third Prize of Tianjin Science and Technology Progress Award
MAJOR NATIONAL LEADERSHIP POSITIONS, SOCIETIES AND BOARDS:
2017-2028 Council Member, Tianjin Society for Cell Biology
2024-2029 Editorial Board Member, Chinese Journal of Cancer Biotherapy
SELECTED PUBLICATIONS:
1. Wang N, Yin J, You N, Yang S, Guo D, Zhao Y, Ru Y, Liu X, Cheng H, Ren Q, Cheng T, Ma X. TWIST1 preserves hematopoietic stem cell function via CACNA1B/Ca2+/mitochondria axis. Blood. 2021; 137 (21): 2907-2919
2. Guo D, Zhao Y, Wang N, You N, Zhu W, Zhang P, Ren Q, Yin J, Cheng T, Ma X. GADD45g acts as a novel tumor suppressor and its activation confers new combination regimens for the treatment of AML. Blood. 2021; 138 (6): 464-479
3. Zhang P, You N, Ding Y, Zhu W, Wang N, Xie Y, Huang W, Ren Q, Qin T, Fu R, Zhang L, Xiao Z, Cheng T, Ma X. Gadd45g insufficiency drives the pathogenesis of myeloproliferative neoplasms. Nature Communications. 2024; 15: 2989
4. Ma X, Xu B, An L, Dong C, Lin Y, Shi Y, Wu K. Vaccine with beta defensin 2-transduced leukemic cells activates innate and adaptive immunity to elicit potent antileukemia responses. Cancer Res. 2006;66(2):1169-1176