Yuxuan Liu received her Ph.D. in molecular and cell biology from the University of Texas at Dallas, while working in the laboraoty of Dr. Michael Q. Zhang. Dr. Liu's doctoral work focused on studying transcriptional regulation using bioinformatics and next-generation sequencing. She then joined the laboratory of Dr. Jian Xu at UT Southwestern Medical Center as a postdoctoral fellow, where she applied computational biology to investigate epigenetic regulation in blood cancers. Dr. Liu's research interests include dissecting enhancer function and regulation in blood cancers and employing computational and multi-omic approaches to understand the initiation and progression of blood cancers.
Ph.D., Molecular and cell biology, The University of Texas at Dallas, Dallas, Texas, US, 2010-2016
MS, Mathematical Sciences, The University of Texas at Dallas, Dallas, Texas, US, 2013-2014
BS, Biotechnology, Shandong University, Jinan, Shandong, China, 2006-2010
Principle Investigator, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 2022-
Senior research scientist, BeiGene Ltd, 2020-2022
Postdoc fellow, UT southwestern medical center, 2016-2020
SELECTED PUBLICATIONS:
1,Xinping Cai; Qianru Zhang; Bolin Liu; Lu Sun; Yuxuan Liu# ; HemaCisDB: An Interactive Database for Analyzing Cis-Regulatory Elements Across Hematopoietic Malignancies, Genomics Proteomics Bioinformatics, 2024 (on line) (通讯作者)
2, Yuxuan Liu*; Zhimin Gu*; Hui Cao; Pranita Kaphle; Junhua Lyu; Yuannyu Zhang; Wenhuo Hu; Stephen S. Chung; Kathryn E. Dickerson; Jian Xu ; Convergence of oncogenic cooperation at single- cell and single-gene levels drives leukemic transformation, Nature Communications, 2021, 12(1): 1-17 （共同第一作者）
3, Zhimin Gu*; Yuxuan Liu*; Yuannyu Zhang; Hui Cao; Junhua Lyu; Xun Wang; Annika Wylie; Simon J. Newkirk; Amanda E. Jones; Michael Lee Jr.1; Giovanni A. Botten; Mi Deng; Kathryn E. Dickerson; Cheng Cheng Zhang; Wenfeng An; John M. Abrams; Jian Xu ; Silencing of LINE-1 retrotransposons is a selective dependency of myeloid leukemia, Nature Genetics, 2021, 53(5): 672-682 （共同第一作者）
4, Kailong Li*; Yuxuan Liu*; Hui Cao; Yuannyu Zhang; Zhimin Gu; Xin Liu; Andy Yu; Pranita Kaphle; Kathryn E Dickerson; Min Ni; Jian Xu ; Interrogation of enhancer function by enhancer- targeting CRISPR epigenetic editing, Nature Communications, 2020, 11(1): 1-16 （共同第一作者）
5, Kailong Li*; Yuannyu Zhang*; Xin Liu*; Yuxuan Liu*; Zhimin Gu; Hui Cao; Kathryn E Dickerson; Mingyi Chen; Weina Chen; Zhen Shao; Min Ni; Jian Xu ; Noncoding variants connect enhancer dysregulation with nuclear receptor signaling in hematopoietic malignancies, Cancer Discovery, 2020, 10(5): 724-745 （共同第一作者）
6, Zhimin Gu*; Yuxuan Liu*; Feng Cai; McKenzie Patrick; Jakub Zmajkovic; Hui Cao; Yuannyu Zhang; Alpaslan Tasdogan; Mingyi Chen; Le Qi; Xin Liu; Kailong Li; Junhua Lyu; Kathryn E Dickerson; Weina Chen; Min Ni; Matthew E Merritt; Sean J Morrison; Radek C Skoda; Ralph J DeBerardinis; Jian Xu ; Loss of EZH2 reprograms BCAA metabolism to drive leukemic transformation, Cancer Discovery, 2019, 9(9): 1228-1247 （共同第一作者）