Zhang Xiaorong is currently engaged in the study of the mechanism of interaction regulation between nucleus and mitochondria, mitochondria and cell fate decision, mitochondrial abnormality and the pathogenic mechanism of diseases. He has presided over several research programs, including NSFC Original Exploration Program (82450106), National Key Research and Development Program of China (2022YFA1303303 & 2019YFA0508700) and NSFC Training Program of the Major Research Plan (91440102).
PhD, Biochemistry and molecular biology, Wuhan University, Wuhan, Hubei, China, 2006-2011
Bachelor, Biological sciences, Northwest Normal University, Lanzhou, Gansu, China, 2002-2006
Professor, State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 2023-
Professor, Key Laboratory for RNA Biology, Institute of Biophysics, Chinese Academy of Science, 2014-2023
Research Assistant, College of life sciences, Wuhan University, 2011-2014
PRINCIPAL HONORS, AWARDS:
2023 First Prize in Natural Science of Hubei Province
SELECTED PUBLICATIONS:
1. Cheng Man, Lu Dan, Li Kexin, Wang Yan, Tong Xiwen, Qi Xiaolong, Yan Chuanzhu, Ji Kunqian, Wang Junlin, Wang Wei, Lv Huijiao, Zhang Xu, Kong Weining, Zhang Jian, Ma Jiaxin, Li Keru, Wang Yaheng, Feng Jingyu, Wei Panpan, Li Qiushuang, Shen Chengyong, Fu Xiang-Dong, Ma Yuanwu, Zhang Xiaorong*. Mitochondrial respiratory complex IV deficiency recapitulates amyotrophic lateral sclerosis. NATURE NEUROSCIENCE, 2025, 28(4).
2. Gao Kuanxing, Cheng Man, Zuo Xinxin, Lin Jinzhong, Hoogewijs Kurt, Murphy Michael P., Fu Xiang-Dong, Zhang Xiaorong*. Active RNA interference in mitochondria. CELL RESEARCH, 2021, 31(2): 219-228.
3. Zhang, X., Zuo, X., Yang, B., Li, Z., Xue, Y., Zhou, Y., Huang, J., Zhao, X., Zhou, J.,Yan, Y., Zhang,H., Guo, P., Sun, H., Guo, L., Zhang, Y., and Fu, X-D *. (2014). microRNA directly enhances mitochondrial translation during muscle differentiation. Cell 158:607-619.
4. Wang, P., Wang, Q., Chen, L., Cao, Z., Zhao, H., Su, R., Wang, N., Ma, X., Shan, J., Chen, X., et al. (2023). RNA-binding protein complex AMG-1/SLRP-1 mediates germline development and spermatogenesis by maintaining mitochondrial homeostasis in Caenorhabditis elegans. Science Bull 68, 1399-1412
5.Zhang, K.*, Zhang, X.*, Cai, Z.*, Zhou, J., Zhou, B., Zhang, K., Cao, R., Zhao, Y., Xue, Y., Zhou, Y., Sun, H., Wu, L., and Fu, X-D. (2018). A novel class of microRNA-recognition elements that function only within open reading frames. Nat Struct Mol Bio. 2018 Nov; 25(11):1019-1027.