Fang Dong is a Research Professor (Principal Investigator) and Doctoral Supervisor at the Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences (CAMS). She also serves as an Assistant Professor at CAMS and is a recipient of the National Natural Science Foundation of China's "Excellent Young Scientists Fund" Program. She is a Committee Member of the Hematological Physiology Branch of the Chinese Association of Physiological Sciences.
After obtaining her Ph.D. under the mentorship of Professor Tao Cheng in 2014, she has been engaged in scientific research, focusing primarily on hematopoietic stem cell biology, with particular expertise in utilizing single-cell technologies to investigate the regulatory mechanisms of hematopoietic stem cell regeneration. Currently, she leads sub-projects under the National Key R&D Program and General Program projects funded by the National Natural Science Foundation of China. She identified the hematopoietic stem cells with super transplantability by serial transplantation and mathematic modeling, and proposed the strategy to mitigate the impairment of cryproservation on cord blood stem cells by anti-oxidants treatment. Her research findings have been published as corresponding (including co-corresponding), or co-first author in journals such as Nature Cell Biology, Blood, and the Journal of Clinical Investigation. She is also dedicated to training young scientists.
Ph.D., Biological medical science, Peking Union Medical College, Beijing, China, 2011-2014
M.D., Laboratory Medicine, Lanzhou University, Lanzhou, China, 2008-2011
B.S., Laboratory Medicine, Hebei Medical University, Shijiazhuang, China, 2006-2008
Professor of Medicine, Institute of Hematology, Chinese Academy of Medical Sciences (CAMS), Peking Union Medical College (PUMC), 2025-
Associate professor of Medicine, Institute of Hematology, Chinese Academy of Medical Sciences (CAMS), Peking Union Medical College (PUMC), 2021-2025
Research Staff of Hematology, Institute of Hematology, Chinese Academy of Medical Sciences (CAMS), Peking Union Medical College (PUMC). 2014-2020
SELECTED PUBLICATIONS:
1. Fang Dong#, et al.. Heterogeneity of high-potency multilineage hematopoietic stem cells and identification of "Super" transplantability. Blood.2025 Jul 31;146(5):546-557
2. Wen Xing#, Fang Dong#, et al..Deletion of p18INK4c enhances both osteogenesis and hematopoietic supportive capacity of bone marrow mesenchymal stromal cells. Stem Cell Res Ther. 2025 Jul 1;16(1):334.
3. Yaojin Huang, Xiaowei Xie, Mengyao Liu, Yawen Zhang, Junye Yang, Wenling Yang, Yu Hu, Saibing Qi, Yahui Feng, Guojun Liu, Shihong Lu, Xuemei Peng, Jinhui Ye, Shihui Ma, Jiali Sun, Lu Wang, Linping Hu, Lin Wang, Xiaofan Zhu, Hui Cheng, Zimin Sun, Junren Chen, Fang Dong*, Yingchi Zhang*, Tao Cheng*. Restoring mitochondrial function promotes hematopoietic reconstitution from cord blood following cryopreservation-related functional decline. J Clin Invest. 2025 Mar 4;135(9): e183607
4. Nini Wang#, Shangda Yang#, Yu Li, Fanglin Gou, Yanling Lv, Xiangnan Zhao, Yifei Wang, Chang Xu, Bin Zhou, Fang Dong*, Zhenyu Ju*, Tao Cheng*, Hui Cheng*. p21/Zbtb18 repress the expression of cKit to regulate the self-renewal of hematopoietic stem cells. Protein & Cell. 2024 Nov 1;15(11):840-857.
5. Huimin Sun#, Linjie Wu#, Xueying Zhao#, Yingying Huo, Peiyuan Dong, Aiming Pang, Yawei Zheng, Yiwen Han, Shihui Ma, Erlie Jiang, Fang Dong*, Tao Cheng*, Sha Hao*. Monocytes as an early risk factor for acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Front in Immunol. 2024 Sep 12:15:1433091.
6. Xiaowei Xie#, Fanglin Gou#, Zhaofeng Zheng, Yawen Zhang, Yingchi Zhang, Fang Dong*, Tao Cheng* , Hui Cheng*. Decoding human bone marrow hematopoietic stem and progenitor cells from fetal to birth. iScience. 2024 Jul 3;27(8):110445
7. Sen Zhang#, Yao Ma#, Lisha Wang, Xialin Li, Yan Dong, Jinhong Wang, Tao Cheng, Fang Dong*, Hideo Ema*. Expansion of Quiescent Hematopoietic Stem Cells under Stress and Nonstress Conditions in Mice. Stem Cell Rev Rep. 2022 Oct;18(7):2388-2402.
8. Fang Dong#, et al.. Analysis and Isolation of Mouse Leukemic Stem Cells. Methods Mol Biol. 2021:2185:51-63.
9. Fang Dong#, et al.. Differentiation of transplanted hematopoietic stem cells tracked by single cell transcriptomic analysis. Nat Cell Biol, 2020 22(6):630-639
10. Fang Dong, et al.., Probing the fate of transplanted hematopoietic stem cells: is the combinational approach “FIT” for purpose? Sci China Life Sci, 2020;63(11):1755-1758