Focusing on the "regulatory mechanisms of megakaryocyte fate determination and platelet regeneration and application," I have achieved multiple original findings: uncovering the endothelial origin of megakaryocytes and discovering their functional heterogeneity; revealing key regulatory mechanisms of megakaryocyte/platelet generation and establishing efficient regeneration strategies; identifying the novel function of platelets as immune sensors and demonstrating the high repair potential of regenerated platelets. As the first or corresponding author, I have published these findings in journals such as Cell Stem Cell, Nature Immunology (cover story), EBioMedicine (cover story), and Cell Reports Medicine, and has been granted five national invention patents. The research papers have been featured in commentaries by Cell Stem Cell and EBioMedicine, recommended by F1000, and widely cited by journals such as Cell and Science. The achievements have twice been selected as one of the "Top Ten Advances in Hematology Research in China." I have also been honored with titles such as Tianjin Young Medical Innovator.
PhD, Genetics, Academy of Military Medical Sciences, Beijing, China, 2011-2014
MS, Genetics, Academy of Military Medical Sciences, Beijing, China, 2008-2011
BS, Biotechnology, Northwest A&F University, Yangling, Shaanxi, China, 2004-2008
Associate Researcher, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 2020-
Assistant Researcher, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 2014-2020
PRINCIPAL HONORS, AWARDS:
2023 Young Top-notch Talent of the National Ten-Thousand Talents Program
2024 Recipient of the Tianjin Outstanding Youth Fund
MAJOR NATIONAL LEADERSHIP POSITIONS, SOCIETIES AND BOARDS:
2023-2026 Young Committee Member, Society for Cell Therapy Research and Application, Chinese Society for Cell Biology
2025-2030 Standing Committee Member, Expert Committee on Aging Intervention and Chronic Disease Prevention and Treatment, China Health Promotion Foundation
SELECTED PUBLICATIONS:
1. Wang H#, He J#, Xu C#, et al. Decoding Human Megakaryocyte Development. Cell Stem Cell. 2021 Mar 4;28(3):535-549.e8.
2. Xu C#, He J#, Wang H#, et al. Single-cell transcriptomic analysis identifies an immune-prone population in erythroid precursors during human ontogenesis. Nat Immunol. 2022 Jul;23(7):1109-1120.
3. Zheng L#, Feng D#, Wu Y, et al. Jiang E*, Zhou J*, Wang H*. Platelets as immune sensors: monitoring immune dynamics and diagnosing disease states across multiple disorders. EBioMedicine. 2026 Feb 19;125:106174.
4. Huang B#, Li L#, Yao S, et al. Wang H*, Liu C*, Zhou J*. Enhanced regenerative and developmental potential of embryonal and stem cell-derived platelets compared to adult platelets. Cell Rep Med. 2025 Aug 19;6(8):102297.