I am interested in developing and applying new technologies in single-cell omics to uncover the molecular heterogeneity and explore the regulatory mechanisms of organ development and diseases, particularly in cardiovascular and blood diseases. In addition, my research interests have broadly centered on developing new computational tools to precisely infer the cell lineage histories based on the multi-modal single-cell epigenomic data. My sustaining and overarching scientific goal is to understand the language of multiple histone marks and probe the function of molecules encoded by the genome.
Ph.D., Molecular medicine, Peking University, Beijing, China, 2016-2022
B.S. Biology, Hubei University, Wuhan, China, 2012-2016
Professor of Medicine, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 2022-
PRINCIPAL HONORS, AWARDS:
2022 Ray Wu Prize
SELECTED PUBLICATIONS:
1. Li, R., Pan, H., Zhang, L., Ma, J., ..., Xiong, H.§, Shi. J.§. CD19 CAR T-Cell Therapy for Autoimmune Hemolytic Anemia. N. Engl. J Med. (2026).
2. Xiong, H.*, §, Wang, Q.*, Li, C. C., He, A.§. Single-cell joint profiling of multiple epigenetic proteins and gene transcription. Sci. Adv. (2024).
3. Xiong, H.*, Luo, Y.*, Wang, Q.*, Yu, X., He, A. Single-cell joint detection of chromatin occupancy and transcriptome enables higher-dimensional epigenomic reconstructions. Nat. Methods (2021).
4. Xiong, H.*, Luo, Y*., Yue, Y*., Zhang, J*., Ai, S., Li, X., Wang, X., Zhang, Y. L., Wei, Y., Li, H. H., Hu, X., Li, C. & He, A. Single-Cell Transcriptomics Reveals Chemotaxis-Mediated Intraorgan Crosstalk During Cardiogenesis. Circ. Res. (2019).
5. Ai, S.*, Xiong, H.*, Li, C. C., Luo, Y., Shi, Q., Liu, Y., Yu, X., Li, C. & He, A. Profiling chromatin states using single-cell itChIP-seq. Nat. Cell Biol. (2019).
6. Wang, Q.*, Xiong, H.*, Ai, S.*, Yu, X.*, Liu, Y.*, Zhang, J. & He, A. CoBATCH for High-Throughput Single-Cell Epigenomic Profiling. Mol. Cell (2019).