造血干细胞发育受到多种因素的精密调控，调控失衡将导致血液发育缺陷或相关疾病。深入系统地研究造血干细胞（HSC）发育中的关键因子及作用机制，对完善调控网络和治疗相关疾病具有重要意义。我们致力于揭示细胞内源因子、微环境及表观遗传修饰在造血干细胞发育中的作用，主要成果包括：转录因子Fev、初级纤毛、炎性信号及表观修饰m6A甲基化调控造血干细胞产生；血液流动及5羟色胺分别影响造血干细胞维持及存活；DNA甲基化和RNA甲基化调控胚胎早期发育；Rac2和Foxn1分别调控T淋巴前体细胞迁移和分化的新机制。我们目前的研究拟从体内发育、疾病模型和作用机制三个层次深入探讨关键调控因子在血液系统发育和血液疾病发生的作用机理，构建相关疾病模型，以期为相关疾病治疗和药物开发提供理论基础。
2009-2013 中国科学院动物研究所 博士
2007-2009 北京科技大学 硕士
2003-2007 江苏大学 学士
2019–2019 中国医学科学院血液学研究所 研究员
2016-2019 中国科学院动物研究所 副研究员
2013-2016 中国科学院动物研究所 博士后
1、国家重点研发计划青年科学家项目，RNA甲基化修饰调控血液血管发育的机制研究，2019/9-2024/8，2018YFA0801200
2、国家自然科学基金面上项目，神经递质5羟色胺调控斑马鱼造血干细胞发育的分子机制，2018/01-2022/12，31771604
3、2016-2018年度中国科协“青年人才托举工程”项目，YESS20160016
4、中国科学院青年创新促进会会员，2017-2020年度
5、国家自然科学青年科学基金项目，Dnmt1调控斑马鱼造血干细胞产生、分化及迁移的分子机制，2015/01-2017/12，31401242
1. Lv P#, Ma D#, Gao S#, Zhang Y, Bae YK, Liang G, Gao S, Choi JH, Kim CH, Wang L*, Liu F*. Generation of foxn1/Casper Mutant Zebrafish for Allograft and Xenograft of Normal and Malignant Cells. Stem Cell Reports. 2020, Aug 7;S2213-6711(20)30297-6. doi: 10.1016/j.stemcr.2020.07.020.
2. Lu X, Zhang Y, Liu F*, and Wang L*. Rac2 Regulates the Migration of T Lymphoid Progenitors to the Thymus During Zebrafish Embryogenesis. J Immunol. 2020, 204(9):2447-2454.
3. Liu ZB, Tu HQ, Kang YS, Xue YY, Ma DY, Zhao CT, Li HY, Wang L*, Liu F*. Primary cilia regulate hematopoietic stem and progenitor cell specification through Notch signaling in zebrafish. Nature Commun. 2019, 10(1):1839.
4. Yang Y#, Wang L#, Han X#, Yang WL#, Zhang M#, Ma HL, Sun BF, Li A, Xia J, Chen J, Heng J, Wu B, Chen YS, Xu JW, Yang X, Yao H, Sun J, Lyu C, Wang HL, Huang Y, Sun YP, Zhao YL, Meng A, Ma J*, Liu F* and Yang YG*. (2019) RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay. Mol Cell. 2019, 75(6):1188-1202.
5. Wang L, Liu ZB, Lin H, Ma DY, Tao QH, Liu F*. Epigenetic regulation of left-right asymmetry by DNA methylation. EMBO J. 2017, 36(20):2987-97
6. Zhang CX#, Chen YS#, Sun BF#, Wang L#, Yang Y#, Ma DY, Lv JH, Heng J, Ding YY, Xue YY, Lu XY, Xiao W, Yang YG*, Liu F*. m6A modulates haematopoietic stem and progenitor cell specification. Nature. 2017, 549(7671):273-76
7. Lv JH#, Wang L#, Gao Y, Ding YQ, Liu F*. 5-hydroxytryptamine synthesized in the aorta-gonad-mesonephros regulates hematopoietic stem and progenitor cell survival. J Exp Med. 2017, 214(2):529-545
8. Liu TH#, Tang YJ#, Huang Y#, Wang L#, Guo XL, Mi JQ, Liu LG, Zhu H, Zhang Y, Chen L, Liu X, Zhang LH, Ye QJ, Li BS, Tang JY, Ford A, Enver T, Liu F*, Chen GQ*, Hong DL*. Expression of the fetal hematopoiesis regulator FEV indicates leukemias of prenatal origin. Leukemia. 2017, 31(5):1079-1086
9. Wang L#, Zhang CX#,, Liu F*. Molecular regulation of hematopoietic stem cell development. Scientia Sinica Vitae. 2016, 46(1);16-24
10. He QP#, Zhang CX#, Wang L#, Zhang PP, Ma DY, Lv JH, Liu F*. Inflammatory signaling regulates hematopoietic stem and progenitor cell emergence in vertebrates. Blood. 2015, 125(7):1098-106
11. Ping XL#, Sun BF#, Wang L#, Xiao W#, Yang X, Wang WJ, Samir A, Shi Y, Lv Y, Chen YS, Zhao X, Li A, Yang Y, Ujwal D, Lou XM, Liu X, Huang J, Yuan WP, Zhu XF, Cheng T, Zhao YL, Wang XQ, Danielsen JMR, Liu F*, Yang YG*. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. Cell Res. 2014, 24(2):177-89
12. Wang L#, Liu TH#, Xu LJ#, Gao Y, Wei YL, Duan C, Chen GQ, Lin S, Patient R, Zhang B, Hong DL, Liu F*. Fev regulates hematopoietic stem cell development via ERK signaling. Blood. 2013, 122(3):367-75
13. Ciau-Uitz A#, Wang L#, Patient R, Liu F*. ETS transcription factors in hematopoietic stem cell development. Blood Cells Mol Dis. 2013, 51(4):248-55
14. Ma DY#, Wang L#, Wang SF#, Gao Y, Wei YL, Liu F*. Foxn1 maintains thymic epithelial cells to support T-cell development via mcm2 in zebrafish. PNAS. 2012, 109(51):21040-5
15. Wang L, Zhang PP, Wei YL, Gao Y, Patient R, Liu F*. A blood flow-dependent klf2a-NO signaling cascade is required for stabilization of hematopoietic stem cell programming in zebrafish embryos. Blood. 2011, 118(15):4102-10