中国医学科学院血液病医院（血液学研究所）研究员，北京协和医学院（长准聘系列）助理教授，博士生导师，获国家级人才计划青年项目。实验室的研究兴趣为血液系统疾病的功能基因组和基因治疗，具体研究方向为1）新型基因编辑工具研发，2）CRISPR高通量功能筛选，3）遗传性疾病基因治疗。研究成果发表在Cell Stem Cell、Journal of Clinical Investigation和Nature Communications等期刊。

2015 中国医学科学院（北京协和协和医学院）基础医学研究所，博士
2010 华中科技大学同济医学院，学士

2021~至今 中国医学科学院血液病医院实验血液学国家重点实验室（研究员），北京协和医学院助理教授（长准聘用系列）
2017~2021 美国哈佛医学院波士顿儿童医院博士后
2016~2017 美国圣裘德儿童研究医院博士后

1. 中国医学科学院引进人才项目，2021-RC310-015，中性粒细胞发育和自发性死亡机制， 2021.09~2026.08
2. 国家重点研发计划青年科学家项目，2021YFA1102300，分子伴侣介导的自噬与造血干细胞衰， 2021.12~2026.08（项目骨干）
3. 中国医学科学院医学与健康科技创新工程项目，2021-I2M-1-041，血液病的细胞与基因治疗机制、新策略及临床应用，2021.10~2025.12（子课题负责人）
4. 细胞生态海河实验室揭榜挂帅项目，HH22KYZX0040，体内造血干细胞基因编辑及其基因治疗，2022.01~2024.12
5. 天津市自然科学基金，21JCQNJC01220，ELANE基因终末外显子移码突变导致重症先天性粒细胞减少症的分子机制研究，2022.10~2023.09
6. 2022年度国家级人才计划青年项目

13. Marsha M. Wheeler^#, Adrienne M. Stilp^#, Shuquan Rao^#, Bjarni V. Halldórsson, Doruk Beyter, Jia Wen, Anna V. Mikhaylova, Caitlin P. McHugh, John Lane, Minzhi Jiang, et al. Whole genome sequencing identifies common and rare structural variants contributing to hematologic traits in the NHLBI TOPMed program. Nat Commun 2022.

12. Yao Yao^#, Jiaxuan Cao^#, Wentian Wang, Boya Liu, Xiaolei Pei, Lei Zhang, Shuquan Rao^*. Highly efficient one-step tagging of endogenous genes in primary cells using CRISPR-Cas ribonucleoproteins. The CRISPR Journal 2022.

11. Yao Yao^#, Hongfei Song^#, Fanshuang Zhang^#, Jibin Liu, Quansheng Feng, Shuquan Rao^*, Cen Jiang^*. Genetic predisposition to blood cell indices in relation to severe COVID-19. J Med Virol 2022 Aug 29.

10. Fuquan Zhang^#*, Shuquan Rao^#, Hongbao Cao, Xiangrong Zhang, Qiang Wang, Yong Xu, Jing Sun, Chun Wang, Jiu Chen, Xijia Xu, et al. Genetic evidence suggests posttraumatic stress disorder as a subtype of major depressive disorder. J Clin Invest 2022, 132 (3):e145942.

9. Shuquan Rao^#, Ancha Baranova^#, Hongbao Cao, Jiu Chen, Xiangrong Zhang, Fuquan Zhang^*. Genetic mechanisms of COVID-19 and its association with smoking and alcohol consumption. Brief Bioinform 2021.

8. Shuquan Rao^#*, Yao Yao^#, Daniel E. Bauer^*. Editing GWAS: experimental approaches to dissect and exploit disease-associated genetic variation. Genome Med 2021, 13:41.

7. Shuquan Rao^#, Yao Yao^#, Josias Soares de Brito^#, Qiuming Yao, Anne H Shen, Ruth E Watkinson, Alyssa L Kennedy, Steven Coyne, Chunyan Ren, Jing Zeng, et al. ELANE neutropenia pathogenicity dissected by human hematopoietic stem cell gene editing. Cell Stem Cell 2021, 28:1-13. Featured article. See commentary in New England Journal of Medicine by Prof. Julia Skokowa and Cell Stem Cell by Prof. Marshall S. Horwitz.

6. Yao Hu^#, Adrienne M Stilp^#, Caitlin P McHugh^#, Shuquan Rao^#, Deepti Jain, Xiuwen Zheng, John Lane, Sébastian Méric de Bellefon, Laura M Raffield, Ming-Huei Chen, et al. Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program. Am J Hum Genet 2021.

5. Yao Yao^#, Fei Ye^#, Kailong Li^#, Peng Xu, Wenjie Tan, Quansheng Feng, Shuquan Rao^*. Genome and epigenome editing identify CCR9 and SLC6A20 as target genes at the 3p21. 31 locus associated with severe COVID-19. Signal Transduct Target Ther 2021.

4. Yao Yao, Jia Yang, Qian Qin, Chao Tang, Zhidan Li, Li Chen, Kailong Li, Chunyan Ren, Lu Chen^*, Shuquan Rao^*. Functional annotation of genetic associations by transcriptome-wide association analysis provides insights into neutrophil development regulation. Commun Biol 2020, 3(1): 790.

3. Sha Liu^#, Shuquan Rao^#, Yong Xu^#, Jun Li^#, Hailiang Huang, Xu Zhang, Hui Fu, Qiang Wang, Hongbao Cao, Ancha Baranova, Chunhui Jin*, Fuquan Zhang*. Identifying common genome-wide risk genes for major psychiatric traits. Hum Genet 2020, 139(2): 185-198.

2. Shuquan Rao^#*, Na Luo^#, Jing Sui, Qi Xu, Fuquan Zhang. Effect of the SIRT1 gene on regional cortical grey matter density in the Han Chinese population. Br J Psychiatry 2018.

1. Yao Yao^#, Jia Yang^#, Yimin Xie, Hai Liao, Baoying Yang, Qi Xu, Shuquan Rao*. No Evidence for Widespread Positive Selection Signatures in Common Risk Alleles Associated with Schizophrenia. Schizophr Bull 2018.