课题组的长期研究方向为炎症机制及干预研究。研究最终目标是阐明炎症相关细胞（如中性粒细胞）和因子在炎症的发生、发展和消退中的作用及规律，并研究和开发靶向干预药物。课题组近20年主要围绕中性粒细胞的死亡、功能及调控机制开展研究，主要研究进展如下：1. 发现中性粒细胞中丝氨酸蛋白酶3（proteinase 3,Pr3）能通过切割活化caspase 3来诱导中性粒细胞凋亡的新的分子机制，此外，还发现Pr3是调控急性髓系白血病细胞分化的新靶点。；2. 六磷酸肌醇激酶-1 (Ip6k1)基因敲除或用TNP抑制IP6K1活性均能够有效的增强宿主对细菌的杀伤能力，但同时减少肺部中性粒细胞的招募进而降低肺部损伤。3. 在国际上率先筛选到一个能在体内外同时高效抑制TNFα和TNFβ功能的全新小分子化合物C87。4. 在国际上率先制备出第一个抗CD3/抗CD20双功能基因工程抗体(diabody) 。目前，课题组一方面将继续和深入上述研究，另一方面将开展髓系细胞与肿瘤的发展与转移的关系以及干预研究。

1996-2000  中国协和医科大学，药学专业，理学硕士

1988-1992  南开大学，生物系分子生物学专业，理学学士

2013/09-至今，中国医学科学院,血液病医院(血液学研究所)，研究员

2004/09-2013/09，中国医学科学院,血液病医院(血液学研究所)，副研究员

1998/12-2007/06，多次公派香港科技大学生物系，访问学者

1998/03-2004/09，中国医学科学院血液学研究所，助理研究员

1. Chen, R#., Cheng, T#., Xie, S#., Sun, S., Chen, M., Zhao, S., Ruan, Q., Ni, S., Rao, M.,Quan, X., Chen, K., Zhang, S.,Cheng, T., Xu, Y*., Chen, Y.*, Yang, Y*.,and Cao,Y*. Effective treatment of acute leukemias in mice by activation of thermogenic adipose tissues. Advanced Science. 2024 Jul 25:e2402332. doi: 10.1002/advs.202402332.

2. Liu, H#., Sun, L#., Zhao, H., Zhao, Z., Zhang, S., Jiang, S., Cheng, T., Wang, X., Wang, T., Shao, Y., Zhu, H., Han, H., Cao, Y., Jiang, E., Cao, Y*., & Xu, Y.*.  Proteinase 3 depletion attenuates leukemia by promoting myeloid differentiation. Cell death and differentiation.2024;31(6):697-710. DOI: 10.1038/s41418-024-01288-4.

3. Lu Chen#, Xianfu Yi#, Piao Guo, Hua Guo, Ziye Chen, Chunyu Hou, Lisha Qi, Yongrong Wang,Chengwen Li, Peng Liu, Yucun Liu, Yuanfu Xu*, Ning Zhang*. The role of bone marrow-derived cells in the origin of liver cancer revealed by single cell sequencing. Cancer Biol Med. 2020; 17: 142-153.

4. Li Ma#, Chunhua She#, Qian Shi, Qiang Yin, Xinxin Ji, Yongrong Wang, Yulong Fan, Xinyao Kong, Peng Li, Zengfeng Sun, Xiaohui Zhang, Zhen Zhang, Jian Wang, Tong Wang, Yuanfu Xu*, Wenliang Li*. TNFα inhibitor C87 sensitizes EGFRvⅢ transfected glioblastoma cells to gefitinib inhibition by a concurrent blockade of TNFα signaling. Cancer Biol Med.2019; 16(3):606-617.

5. Kutay Karatepe#, Haiyan Zhu#, Xiaoyu Zhang#, Rongxia Guo, Hiroto Kambara, Fabien Loison, Peng Liu, Hongbo Yu, Qian Ren, Xiao Luo, John Manis, Tao Cheng, Fengxia Ma, Yuanfu Xu*, and Hongbo R. Luo*. Proteinase 3 Limits the Number of Hematopoietic Stem and Progenitor Cells. Stem Cell Reports. 2018, 11(5): 1092–1105..

6. Qingming Hou^#, Fei Liu^#, Anutosh Chakraborty. Yonghui Jia, Amit Prasad, Hongbo Yu, Li Zhao; Keqiang Ye, Solomon H, Solomon H. Snyder, Yuanfu Xu*, Hongbo R. Luo *. Inhibition of inositol hexakisphosphate kinase 1(IP6K1) enhances host defenses while suppressing neutrophil-mediated pulmonary damage in bacterial pneumonia. Sci Transl Med, 2018 ,4;10(435).

7. Fabien Loison, Haiyan Zhu, Kutay Karatepe, Anongnard Kasorn, Peng Liu, Keqiang Ye, Jiaxi Zhou, Shannan Cao, Haiyan Gong, Dieter E. Jenne, Eileen Remold-O’Donnell, Yuanfu Xu *, and Hongbo R. Luo *. Proteinase 3-dependant caspase-3 cleavage mediates neutrophil death and inflammation. J Clin Invest. 2014;124(10):4445-58.

8. Li Ma, Haiyan Gong, Haiyan Zhu, Qing Ji, Peng Liu, Shannan Cao, Jianfeng Yao, Pei Shu, Mingzhe Han, Xiaotong Ma, Dongsheng xiong, Hongbo R. Luo,Fei Wang, Jiaxi Zhou* & Yuanfu Xu*. A Novel Small-molecule TNFα Inhibitor Attenuates Inflammation in a Hepatitis Mouse Model. J Bio Chem, 2014;289:12457-12466.

9. Xu Y, Li H, Bajrami B, Kwak H, Cao S, Liu P, Zhou J, Zhou Y, Zhu H, Ye K, Luo HR*. Cigarette smoke(CS) and nicotine delay neutrophil spontaneous death via suppressing production of diphosphoinositol pentakisphosphate. PNAS. 2013;110(19):7726-31.

10. Yuanfu Xu^#, Fabien Loison^#, and Hongbo R. Luo* .Neutrophil spontaneous death is mediated by downregulation of autocrine signaling through GPCR,PI3Kγ, ROS, and actin. PNAS. 2010;107: 2950–2955.