课题组的长期研究方向为炎症机制及干预研究。研究最终目标是阐明炎症相关细胞（如中性粒细胞）和因子在炎症的发生、发展和消退中的作用及规律，并研究和开发靶向干预的药物。课题组近10多年主要围绕中性粒细胞的死亡、功能及调控机制开展研究，主要研究进展如下：1. 发现中性粒细胞中丝氨酸蛋白酶3（proteinase 3,Pr3）能通过切割活化caspase 3来诱导中性粒细胞凋亡的新的分子机制；2. 六磷酸肌醇激酶-1 (Ip6k1)基因敲除或用TNP抑制IP6K1活性均能够有效的增强宿主对细菌的杀伤能力，但同时减少肺部中性粒细胞的招募进而降低肺部损伤。3.筛选到一个能在体外和动物体内高效抑制肿瘤坏死因子功能的全新小分子化合物C87。目前，课题组一方面将继续和深入上述研究，另一方面将开展炎症与自身免疫性疾病的关系以及髓系细胞与肿瘤的发展与转移的关系研究。

1996-2000  中国协和医科大学，药学专业，理学硕士

1988-1992  南开大学，生物系分子生物学专业，理学学士

2013/09-至今，中国医学科学院,血液病医院(血液学研究所)，研究员

2004/09-2013/09，中国医学科学院,血液病医院(血液学研究所)，副研究员

1998/12-2007/06，多次公派香港科技大学生物系，访问学者

1998/03-2004/09，中国医学科学院血液学研究所，助理研究员

1. Lu Chen#, Xianfu Yi#, Piao Guo, Hua Guo, Ziye Chen, Chunyu Hou, Lisha Qi, Yongrong Wang,Chengwen Li, Peng Liu, Yucun Liu, Yuanfu Xu*, Ning Zhang*. The role of bone marrow-derived cells in the origin of liver cancer revealed by single cell sequencing. Cancer Biol Med. 2020; 17: 142-153.

2. Li Ma#, Chunhua She#, Qian Shi, Qiang Yin, Xinxin Ji, Yongrong Wang, Yulong Fan, Xinyao Kong, Peng Li, Zengfeng Sun, Xiaohui Zhang, Zhen Zhang, Jian Wang, Tong Wang, Yuanfu Xu*, Wenliang Li*. TNFα inhibitor C87 sensitizes EGFRvⅢ transfected glioblastoma cells to gefitinib inhibition by a concurrent blockade of TNFα signaling. Cancer Biol Med.2019; 16(3):606-617.

3. Kutay Karatepe#, Haiyan Zhu#, Xiaoyu Zhang#, Rongxia Guo, Hiroto Kambara, Fabien Loison, Peng Liu, Hongbo Yu, Qian Ren, Xiao Luo, John Manis, Tao Cheng, Fengxia Ma, Yuanfu Xu*, and Hongbo R. Luo*. Proteinase 3 Limits the Number of Hematopoietic Stem and Progenitor Cells. Stem Cell Reports. 2018, 11(5): 1092–1105..

4. Qingming Hou^#, Fei Liu^#, Anutosh Chakraborty. Yonghui Jia, Amit Prasad, Hongbo Yu, Li Zhao; Keqiang Ye, Solomon H, Solomon H. Snyder, Yuanfu Xu*, Hongbo R. Luo *. Inhibition of inositol hexakisphosphate kinase 1(IP6K1) enhances host defenses while suppressing neutrophil-mediated pulmonary damage in bacterial pneumonia. Sci Transl Med, 2018 ,4;10(435).

5. Shannan Cao, Peng Liu, Haiyan Zhu, Haiyan Gong, Jianfeng Yao, Yawei Sun, Guangfeng Geng, Tong Wang, Sizhou Feng, Mingzhe Han, Jiaxi Zhou, Yuanfu Xu*. Extracellular Acidification Acts as a Key Modulator of Neutrophil Apoptosis and Functions. PLoS ONE, 2015; 10(9):e0137221. doi:10.1371/journal. pone.0137221

6. Fabien Loison, Haiyan Zhu, Kutay Karatepe, Anongnard Kasorn, Peng Liu, Keqiang Ye, Jiaxi Zhou, Shannan Cao, Haiyan Gong, Dieter E. Jenne, Eileen Remold-O’Donnell, Yuanfu Xu *, and Hongbo R. Luo *. Proteinase 3-dependant caspase-3 cleavage mediates neutrophil death and inflammation. J Clin Invest. 2014;124(10):4445-58.

7. Li Ma, Haiyan Gong, Haiyan Zhu, Qing Ji, Peng Liu, Shannan Cao, Jianfeng Yao, Pei Shu, Mingzhe Han, Xiaotong Ma, Dongsheng xiong, Hongbo R. Luo,Fei Wang, Jiaxi Zhou* & Yuanfu Xu*. A Novel Small-molecule TNFα Inhibitor Attenuates Inflammation in a Hepatitis Mouse Model. J Bio Chem, 2014;289:12457-12466.

8. Xu Y, Li H, Bajrami B, Kwak H, Cao S, Liu P, Zhou J, Zhou Y, Zhu H, Ye K, Luo HR*. Cigarette smoke(CS) and nicotine delay neutrophil spontaneous death via suppressing production of diphosphoinositol pentakisphosphate. PNAS. 2013;110(19):7726-31.

9. Yuanfu Xu^#, Fabien Loison^#, and Hongbo R. Luo* .Neutrophil spontaneous death is mediated by downregulation of autocrine signaling through GPCR,PI3Kγ, ROS, and actin. PNAS. 2010;107: 2950–2955.