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原佳沛
北京协和医学院助理教授(长准聘系列),研究员,博导
课题组围绕“三维基因组调控与肿瘤遗传变异功能机制”,建立了从致病变异识别到分子机制解析,再到临床转化的研究体系。取得一系列重要学术成果,近五年来以通讯/第一作者身份在 Cancer Discovery、Molecular Cancer、Nature Communications(2篇)、Journal of Clinical Investigation、Genome Medicine 、Cancer Letters、Biomarker Research等期刊发表论文10篇,其中2篇影响因子>30, 6篇影响因子>10,累计引用次数1500余次,H-index指数14,开发的方法获得国家发明专利授权1项。课题组主页详见:http://yuanlab.bioailab.com/.
研究概述
教育经历
工作经历
主持项目
代表性成果及文章
主要通过整合肿瘤患者的基因组学、三维基因组学和表观组学数据,围绕肿瘤患者的靶点开展一系列系统性研究,有效提高了靶基因的鉴定效率和准确度,为肿瘤患者的精准诊疗提出了新策略,对肿瘤患者的精准分型提出了新的理论依据。

2012-2017    清华大学     博士

2008-2012    山东大学     学士

2023-至今  协和准长聘助理教授,研究员

2021-2022  中国医学科学院血液病医院(中国医学科学院血液学研究所)副研究员

2017-2020  美国德克萨斯大学西南医学中心       博士后

1. 国家自然科学基金委青年科学基金项目,2023/1-2025/12。

2. 医科院创新工程-医学健康领军科技人才养募专项,2022/12-2027/11。

3. 医科院创新工程-科技人才支持专项协和新星项目,2023/11-2028/10。

4. 北京协和医学院“中央高校基本科研业务费”,2021/1-2022/12。

1. Xiaoxiao Yang, Yang Tong, Yuting Wang, Peng Xie, Xin Li*, Jiapei Yuan*, Yang Yang*. Single-cell profiling defines cellular ecosystems and malignant cell state coupling across pan-cancer tumor microenvironments. Molecular Cancer. 2026 Jul 25.

2. Huimin Liu#, Yang Tong#, Meijuan Wu#, Zhuoxin Zhang, Yao Yao, Zhanqi Li, Yin Shi, Zhen Yu, Gang An, Lugui Qiu, Yang Yang*, Haiyan Yang*, Dehui Zou*, Jiapei Yuan*. Single-cell transcriptomic mapping of immune heterogeneity across angioimmunoblastic T-cell lymphoma subtypes. Biomarker Research. 2026 May 22;14(52). PMID: 42174674.

3. Jiapei Yuan#, *, Yang Tong#, Le Wang, Xiaoxiao Yang, Xiaochuan Liu, Meng Shu, Zekun Li, Wen Jin, Chenchen Guan, Yuting Wang, Qiang Zhang*, Yang Yang*. A compendium of genetic variations associated with promoter usage across 49 human tissues. Nature Communications, 2024 Oct 9;15(1):8758. PMID: 39384785.

4. Jiapei Yuan#*, Jingliao Zhang#, Beibei Zhao, Fang Liu, Tianfeng Liu, Yongjuan Duan, Yumei Chen, Xiaojuan Chen, Yao Zou, Li Zhang, Ye Guo, Wenyu Yang, Yang Yang, Jun Wei*, Xiaofan Zhu*, Yingchi Zhang*. Single-cell transcriptomic analysis of the immune microenvironment in pediatric acute leukemia. Cancer Letters, 2024 Jun 4:217018. PMID: 38844062.

5. Xiaochuan Liu#, Hao Chen#, Zekun Li, Xiaoxiao Yang, Wen Jin, Yuting Wang, Jian Zheng, Long Li, Chenghao Xuan, Jiapei Yuan*, Yang Yang*. InPACT: a computational method for accurate characterization of intronic polyadenylation from RNA sequencing data. Nature Communications, 2024 Mar 22;15(1):2583. PMID: 38519498.

6. Zekun Li#, Gerui Liu#, XiaoXiao Yang#, Meng Shu, Wen Jin, Yang Tong, Xiaochuan Liu, Yuting Wang, Jiapei Yuan*, Yang Yang*. An atlas of cell-type-specific interactome networks across 44 human tumor types. Genome Medicine, 2024 Feb 12;16(1):30. PMID: 38347596.

7. Jiapei Yuan#, Yang Tong#, Xiaochuan Liu, Mulin Jun Li, Qiang Zhang*, Yang Yang*. eaQTLdb: An atlas of enhancer activity quantitative trait loci across cancer types. International Journal of Cancer, 2023 Jul 1;153(1):111-119, PMID: 36840614.

8. Jiapei Yuan, Kathleen E Houlahan, Susmita G Ramanand, Sora Lee, GuemHee Baek, Yang Yang, Yong Chen, Douglas W Strand, Michael Q Zhang, Paul C Boutros, Ram S Mani*. Prostate cancer transcriptomic regulation by the interplay of germline risk alleles, somatic mutations and 3D-genomic architecture. Cancer Discovery, 2022, Dec 2;12(12):2838-2855, PMID: 36108240.

9. Susmita G Ramanand#, Yong Chen#, Jiapei Yuan#, Kelly Daescu, Maryou Bk Lambros, Kathleen E Houlahan, Suzanne Carreira, Wei Yuan, GuemHee Baek, Adam Sharp, Alec Paschalis, Mohammed Kanchwala, Yunpeng Gao, Adam Aslam, Nida Safdar, Xiaowei Zhan, Ganesh V Raj, Chao Xing, Paul C Boutros, Johann de Bono, Michael Q Zhang*, Ram S Mani*. The Landscape of RNA Polymerase II Associated Chromatin Interactions in Prostate Cancer. Journal of Clinical investigation, 2020 Aug 3;130(8):3987-4005, PMID: 32343676.

10. Jiapei Yuan#, Jingrui Li#, Yang Yang, Chang Tan, Yumin Zhu, Long Hu, Yijun Qi*, Zhi John Lu*. Stress-responsive regulation of long non-coding RNA polyadenylation in Oryza sativa. The Plant Journal, 2018 Mar;93(5):814-827, PMID: 29265542.

11. Jiapei Yuan#, Ye Zhang#, Jinsong Dong, Yuzhe Sun, Boon L Lim, Dong Liu*, Zhi John Lu*. Systematic characterization of novel lncRNAs responding to phosphate starvation in Arabidopsis thaliana. BMC Genomics, 2016 Aug 18;17:655, PMID: 27538394.

12. Chao Di#, Jiapei Yuan#, Yue Wu, Jingrui Li, Huixin Lin, Long Hu, Ting Zhang, Yijun Qi, Mark B Gerstein, Yan Guo, Zhi John Lu*. Characterization of stress-responsive lncRNA in Arabidopsis Thaliana by integrating expression, epigenetic and structural features. The Plant Journal, 2014 Dec;80(5):848-61, PMID: 25256571. (ESI highly cited paper, in the top 1% of the academic field of Plant & Animal Science).