2007年军事医学科学院遗传学博士

2001年第二军医大学内科学硕士

2025-至今  协和长聘副教授，研究员

2017-2024  暨南大学基础医学与公共卫生学院，研究员

2008-2016  军事医学科学院生物工程研究所，助研/副研

1. 国家自然科学基金重点项目，32630029，卵黄囊血管内皮细胞的造血谱系命运，2027/01-2031/12

2. 国家重点研发计划课题，2024YFA1108301，免疫谱系发育及其微环境调控，2024/12-2027/11

3. 国家重点研发计划课题，2020YFA0112402，特定中胚层干细胞体内谱系命运决定的关键机制研究，2020/10-2024/12

4. 国家自然科学基金重大项目课题，81890991，造血细胞异质性的形成规律及调控机制，2019/01-2023/12

5. 国家自然科学基金面上项目，31871173，单细胞水平解析胚胎血管内皮细胞的造血特化，2019/01-2022/12

6. 国家重点研发计划课题，2016YFA0100601，HSC的发育规律及调控机制，2016/07-2020/12

7. 国家自然科学基金重大研究计划（培育项目），91439128，平滑肌细胞Smad4信号维持大血管稳态抑制主动脉瘤发生及进展的机制研究，2015/01-2017/12

8. 国家自然科学基金面上项目，81370596，Smad信号调控血管内皮细胞生血命运的功能和机制，2014/01-2017/12

9. 国家自然科学基金面上项目，31171410，Smad4和PTEN协同维持小鼠脑血管完整性的功能及机制，2012/01-2015/12

10. 国家自然科学基金面上项目，30871437，Smad4在小鼠胚胎造血发育中的调控作用及相关机制，2009/01-2011/12

1. Zhenyu Xiao#*, Yandong Gong#, Xiaolong Yang#, Nannan He#, Xinyuan Wang, Guoju You, Hanlin Zhu, Yingping Liang, Xinwei Xie, Baoqi Fang, Gaoke Liu, Bing Liu*, Yu Lan*. Epiblast diversification and blood formation in a human pregastrula. Nature. 2026 Aug;656(8127):434-442.

2. Yuzhe Chen#, Chaojie Wang#, Kangyu Huang#, Guoju You#, Bing Liu*, Yu Lan*. A yolk sac-derived hepatic γδ T cell subpopulation develops in a hematopoietic stem cell- and thymus-independent manner. Protein & Cell. 2026 Jun 3:pwag037.

3. Xiaoyu Su, Zhaoqun Deng*, Yu Lan*, Bing Liu*, Chen Liu*. Helper ILCs in the human hematopoietic system. Trends in Immunology. 2025 Mar;46(3):244-257.

4. Yanli Ni#, Guoju You#, Yandong Gong#, Xiaoyu Su#, Yuan Du#, Xiaoshuang Wang#, Xiaochen Ding, Qingfeng Fu, Man Zhang, Tao Cheng*, Yu Lan*, Bing Liu*, Chen Liu*. Human yolk sac-derived innate lymphoid-biased multipotent progenitors emerge prior to hematopoietic stem cell formation. Developmental Cell. 2024 Oct 7;59(19):2626-2642.e6.

5. Haizhen Wang#, Di Liu#, Haifeng Chen#, Yuqing Jiao, Haixin Zhao, Zongcheng Li, Siyuan Hou, Yanli Ni, Rong Zhang, Jinyong Wang, Jie Zhou*, Bing Liu*, Yu Lan*. Nupr1 Negatively Regulates Endothelial to Hematopoietic Transition in the Aorta-Gonad-Mesonephros Region. Advanced Science. 2023 Feb;10(6):e2203813.

6. Changlu Xu#, Jian He#, Hongtao Wang#, Yingnan Zhang#, Jing Wu#, Lu Zhao#, Yue Li, Jie Gao, Guangfeng Geng, Bingrui Wang, Xiaoyuan Chen, Zhaofeng Zheng, Biao Shen, Yang Zeng, Zhijie Bai, Hua Yang, Shujuan Shi, Fang Dong, Shihui Ma, Erlie Jiang, Tao Cheng, Yu Lan*, Jiaxi Zhou*, Bing Liu*, Lihong Shi*. Single-cell transcriptomic analysis identifies an immune-prone population in erythroid precursors during human ontogenesis. Nature Immunology. 2022 Jul;23(7):1109-1120.

7. Siyuan Hou#, Zongcheng Li#, Ji Dong#, Yun Gao#, Zhilin Chang#, Xiaochen Ding#, Shuaili Li, Yunqiao Li, Yang Zeng, Qian Xin, Baihan Wang, Yanli Ni, Xiaowei Ning, Yuqiong Hu, Xiaoying Fan, Yu Hou, Xianlong Li, Lu Wen, Bin Zhou, Bing Liu*, Fuchou Tang*, Yu Lan*. Heterogeneity in endothelial cells and widespread venous arterialization during early vascular development in mammals. Cell Research. 2022 Apr;32(4):333-348.

8. Yu Lan*. Deciphering the continuum of hemogenic endothelium differentiation. Blood. 2022 Jan 20;139(3):308-310.

9. Xianlong Li#, Di Liu#, Linlin Zhang, Haizhen Wang, Yunqiao Li, Zongcheng Li, Aibin He, Bing Liu, Jie Zhou*, Fuchou Tang*, Yu Lan*. The comprehensive DNA methylation landscape of hematopoietic stem cell development. Cell Discovery. 2021 Sep 21;7(1):86

10. Zhilei Bian#, Yandong Gong#, Tao Huang#, Christopher Z. W. Lee#, Lihong Bian#, Zhijie Bai#, Hui Shi#, Yang Zeng, Chen Liu, Jian He, Jie Zhou, Xianlong Li, Zongcheng Li, Yanli Ni, Chunyu Ma, Lei Cui, Rui Zhang, Jerry K. Y. Chan, Lai Guan Ng, Yu Lan*, Florent Ginhoux*, Bing Liu*. Deciphering Human Macrophage Development at Single Cell Resolution. Nature. 2020 Jun;582(7813):571-576.

11. Siyuan Hou#, Zongcheng Li#, Xiaona Zheng#, Yun Gao#, Ji Dong#, Yanli Ni#, Xiaobo Wang, Yunqiao Li, Xiaochen Ding, Zhilin Chang, Shuaili Li, Yuqiong Hu, Xiaoying Fan, Yu Hou, Lu Wen, Bing Liu*, Fuchou Tang*, Yu Lan*. Embryonic endothelial evolution towards first hematopoietic stem cells revealed by single-cell transcriptomic and functional analyses. Cell Research. 2020 May;30(5):376-392.

12. Yang Zeng#, Chen Liu#, Yandong Gong#, Zhijie Bai#, Siyuan Hou#, Jian He, Zhilei Bian, Zongcheng Li, Yanli Ni, Jing Yan, Tao Huang, Hui Shi, Chunyu Ma, Xueying Chen, Jinyong Wang, Lihong Bian, Yu Lan*, Bing Liu*, Hongbo Hu*. Single-Cell RNA Sequencing Resolves Spatiotemporal Development of Pre-thymic Lymphoid Progenitors and Thymus Organogenesis in Human Embryos. Immunity. 2019 Nov 19;51(5):930-948.e6.

13. Yang Zeng#, Jian He#, Zhijie Bai#, Zongcheng Li#, Yandong Gong, Chen Liu, Yanli Ni, Junjie Du, Chunyu Ma, Lihong Bian, Yu Lan*, Bing Liu*. Tracing the first hematopoietic stem cell generation in human embryo by single-cell RNA sequencing. Cell Research. 2019 Nov;29(11):881-894.

14. Jie Zhou#, Jiayue Xu#, Linlin Zhang#, Siqi Liu#, Yanni Ma#, Xin Wen, Junkai Hao, Zongcheng Li, Yanli Ni, Xianlong Li, Fan Zhou, Qingqing Li, Fang Wang, Xiaoshuang Wang, Yanmin Si, Pengcheng Zhang, Chen Liu, Marisa Bartolomei, Fuchou Tang, Bing Liu*, Jia Yu*, Yu Lan*. Combined single-cell profiling of lncRNAs and functional screening reveals H19 is pivotal for embryonic hematopoietic stem cell development. Cell Stem Cell. 2019 Feb 7;24(2):285-298.e5.

15. Hui Ye#, Xiaobo Wang#, Zongcheng Li, Fan Zhou, Xianlong Li, Yanli Ni, Weijing Zhang, Fuchou Tang, Bing Liu*, Yu Lan*. Clonal analysis reveals remarkable functional heterogeneity during hematopoietic stem cell emergence. Cell Research. 2017 Aug;27(8):1065-1068.