Toshio Suda教授主要围绕造血干细胞及其微环境开展研究，重点研究造血干细胞龛、干细胞静息与自我更新以及造血干细胞衰老机制，阐明了骨髓微环境对造血干细胞维持和功能调控的重要作用，并建立了氧化应激与造血干细胞衰老之间的联系。

1985  Jichi Medical University 医学（血液学）博士

1974  Yokohama City University School of Medicine临床医学学士

2024-至今  中国医学科学院血液病医院（中国医学科学院血液学研究所）研究员，北京协和医学院招聘教授

2014- 2024 National University of Singapore Cancer Science Institute 教授

2014- 2023  Kumamoto University International Research Center for Medical Sciences (IRCMS) 教授

2002- 2015 Keio University School of Medicine 教授

1992- 2002  Kumamoto University School of Medicine  Institute of Molecular Embryology and Genetics 教授

1983- 1991 Jichi Medical School  Division of Hematology    副教授

1. 造血干细胞衰老的调控，中国医学科学院医学与健康科技创新工程，2024-I2M-3-017，主持，2024/05-2027/05

2. Unravelling Molecular Mechanisms of Hematopoietic Stem Cell Aging，国家自然科学基金委国际合作与交流项目，8249100024，主持，2025/01-2027/12

1. Yang C, Wang T, Chai Y, Wang L, Wang Y, Wang W, Dong F, Suda T*. P-selectin delineates conserved functional heterogeneity in early hematopoietic stem cell aging in humans and mice. EMBO J. 2026 Sep;45(18):6421-6449.

2. Xu C, Lv X, Yang S, Lv Y, Zheng Y, Wang YX, Hui Y, Sun G, Zhao X, Ma LY, Duan H, Zhang L, Pu S, Sun L, Li X, He Y, Fang W, Yang M, Suda T*, Chen Q*, Cheng T*, Cheng H*. Procr+ endothelial progenitor cells govern hematopoiesis through fine-tuning mesenchymal stem cell niche signals. Blood. 2026 Aug 13;148(7):841-855.

3. Noguchi G, Baba M, Ohtake S, Jikuya R, Mitome T, Kawaura S, Aomori K, Iribe Y, Nagasaka H, Krisna LAW, Funasaki S, Muraoka E, Fujii S, Tsuzuki T, Kato I, Furuya M, Nagashima Y, Nishizawa H, Kamba T, Kuraoka S, Kawagoe T, Mizuki N, Tatenuma T, Ueno D, Kawahara T, Ito H, Komeya M, Ito Y, Muraoka K, Uemura H, Tamura T, Ogawa T, Suda T, Yao M, Makiyama K, Nakagawa H, Shuch BM, Ricketts CJ, Schmidt LS, Linehan WM, Nishinakamura R, Hasumi H. Genetically Engineered Human iPS Cell-Derived Kidney Organoid Recapitulates an Early Stage of ALK Fusion Gene-Associated Renal Tumorigenesis. Mol Cancer Res. 2026 Apr 2;24(4):221-231.

4. Chen R, Dong Q, Zhou L, He H, Du Y, Sun Q, Suda T, Cheng T, Wang J. Aging-declined RNA exportation impairs hematopoietic stem cells by inducing R-loop. Haematologica. 2026 Jan 1;111(1):245-258.

5. Tanaka Y, Kubota Y, Kikuchi R, Yabushita T, Kimura T, Lieberam I, Barlow JL, Bramley JW, Fukushima T, Sakuma C, Shibata T, Nakagawa M, Kurosawa Y, Maruyama T, Okumura CJ, Arima Y, Sato Y, Ono Y, Akuta T, Mizuno H, Kent DG, Jessell TM, Goyama S, Nishikii H, Kimura S, Yamazaki S, Suda T, Kitamura T. Prospective isolation of mouse and human hematopoietic stem cells using PLXDC2. Commun Biol. 2025 Dec 10;9(1):20.

6. Jikuya R, Johnson TA, Muraoka E, Noguchi G, Maekawa S, Obara W, Numakura K, Habuchi T, Maejima K, Sasagawa S, Kanazashi Y, Lee H, Song WJ, Sasagawa H, Mitome T, Ohtake S, Kawaura S, Iribe Y, Aomori K, Nagasaka H, Tatenuma T, Ueno D, Komeya M, Ito H, Ito Y, Muraoka K, Kawahara T, Furuya M, Kato I, Hamanoue H, Nishiyama A, Tamura T, Baba M, Suda T, Kodama T, Ogawa T, Uemura H, Yao M, Tsuzuki T, Nagashima Y, Miura Y, Kimura G, Imoto S, Momozawa Y, Fujii S, Makiyama K, Hasegawa T, Shuch BM, Ricketts CJ, Schmidt LS, Linehan WM, Nakagawa H, Hasumi H. Comparative transcriptome atlas as an assistive modality for complex classification of rare kidney cancers. Nat Commun. 2025 Nov 24;16(1):10340. doi: 10.1038/s41467-025-65303-z.

7. Yamashita M, Li J, Tran VL, Haltalli MLR, McKinney-Freeman S, Suda T*. Balancing hematopoietic stem cell self-renewal and differentiation activities throughout ontogeny and aging. Exp Hematol. 2025 Sep;149:104820.

8. Nakata Y, Ueda T, Sera Y, Koizumi M, Imamura K, Kanai A, Ikeda KI, Yamasaki N, Nagamachi A, Kobatake K, Taguchi M, Sotomaru Y, Ichinohe T, Honda ZI, Nakamura T, Manabe I, Suda T, Takubo K, Kaminuma O, Honda H. JMJD3-mediated senescence is required to overcome stress-induced hematopoietic defects. EMBO Rep. 2025 Aug;26(15):3831-3855.

9. Dong F, Zhang S, Zhu C, Yang Z, Wang L, Ma Y, Lu J, Li X, Wang X, Wang N, Zhang S, Xie M, Wang J, Zhang X, Zheng Y, Ma S, Ema H, Cheng H, Hao S, Suda T, Lan Y, Liu B, Zhu P, Chen J, Cheng T. Heterogeneity of high-potency multilineage hematopoietic stem cells and identification of "Super" transplantability. Blood. 2025 Jul 31;146(5):546-557.

10. Yogo T, Iwamoto Y, Becker HJ, Kimura T, Ishida R, Sugiyama-Finnis A, Yokomizo T, Suda T, Ota S, Yamazaki S. Quantitative phase imaging with temporal kinetics predicts hematopoietic stem cell diversity. Nat Commun. 2025 Jul 14;16(1):6496.

11. Totani H, Matsumura T, Yokomori R, Umemoto T, Takihara Y, Yang C, Chua LH, Watanabe A, Sanda T, Suda T*. Mitochondria-enriched hematopoietic stem cells exhibit elevated self-renewal capabilities, thriving within the context of aged bone marrow. Nat Aging. 2025 May;5(5):831-847.

12. Chai Y, Yang C, Dong F, Ema H, Suda T*. Development of an efficient differentiation culture system of murine HSC into megakaryocytes. Biochem Biophys Res Commun. 2025 Mar 8;752:151463.

13. Yogo T, Becker HJ, Kimura T, Iwano S, Kuchimaru T, Miyawaki A, Yokomizo T, Suda T, Iwama A, Yamazaki S. Progenitor effect in the spleen drives early recovery via universal hematopoietic cell inflation. Cell Rep. 2025 Feb 25;44(2):115241.

14. Morishima T, Fakruddin M, Kanamori Y, Masuda T, Ogawa A, Wang Y, Schoonenberg VAC, Butter F, Arima Y, Akaike T, Moroishi T, Tomizawa K, Suda T, Wei FY, Takizawa H. Mitochondrial translation regulates terminal erythroid differentiation by maintaining iron homeostasis. Sci Adv. 2025 Feb 21;11(8):eadu3011.

15. Yang C, Suda T*. Microenvironmental dynamics in steady-state and stress erythropoiesis. Blood Sci. 2025 Feb 11;7(1):e00219.

16. Nishizawa H, Funasaki S, Ma W, Kubota Y, Watanabe K, Arima Y, Kuroda S, Ito T, Furuya M, Motoshima T, Nishiyama A, Mehanna S, Satou Y, Hasumi H, Jikuya R, Makiyama K, Tamura T, Oike Y, Tanaka Y, Suda T, Schmidt LS, Linehan WM, Baba M, Kamba T. HIF1α Plays a Crucial Role in the Development of TFE3-Rearranged Renal Cell Carcinoma by Orchestrating a Metabolic Shift Toward Fatty Acid Synthesis. Genes Cells. 2025 Jan;30(1):e13195.

17. Brestoff JR, Singh KK, Aquilano K, Becker LB, Berridge MV, Boilard E, Caicedo A, Crewe C, Enríquez JA, Gao J, Gustafsson ÅB, Hayakawa K, Khoury M, Lee YS, Lettieri-Barbato D, Luz-Crawford P, McBride HM, McCully JD, Nakai R, Neuzil J, Picard M, Rabchevsky AG, Rodriguez AM, Sengupta S, Sercel AJ, Suda T, Teitell MA, Thierry AR, Tian R, Walker M, Zheng M. Recommendations for mitochondria transfer and transplantation nomenclature and characterization. Nat Metab. 2025 Jan;7(1):53-67.

18. Ma W, Ahmad SAI, Hashimoto M, Khalilnezhad A, Kataoka M, Arima Y, Tanaka Y, Yanagi S, Umemoto T, Suda T*. MITOL deficiency triggers hematopoietic stem cell apoptosis via ER stress response. EMBO J. 2024 Feb;43(3):339-361.

19. Yang C, Yokomori R, Chua LH, Tan SH, Tan DQ, Miharada K, Sanda T, Suda T*. Mitochondria transfer mediates stress erythropoiesis by altering the bioenergetic profiles of early erythroblasts through CD47. J Exp Med. 2022 Dec 5;219(12):e20220685.

20. Matsumura T*, Totani H, Gunji Y, Fukuda M, Yokomori R, Deng J, Rethnam M, Yang C, Tan TK, Karasawa T, Kario K, Takahashi M, Osato M, Sanda T, Suda T*. A Myb enhancer-guided analysis of basophil and mast cell differentiation. Nat Commun. 2022 Nov 18;13(1):7064.

21. Yokomizo T, Ideue T, Morino-Koga S, Tham CY, Sato T, Takeda N, Kubota Y, Kurokawa M, Komatsu N, Ogawa M, Araki K, Osato M, Suda T*. Independent origins of fetal liver haematopoietic stem and progenitor cells. Nature. 2022 Sep;609(7928):779-784.

22. Matsumura T*, Nakamura-Ishizu A, Muddineni SSNA, Tan DQ, Wang CQ, Tokunaga K, Tirado-Magallanes R, Sian S, Benoukraf T, Okuda T, Asou N, Matsuoka M, Osato M, Suda T*. Hematopoietic stem cells acquire survival advantage by loss of RUNX1 methylation identified in familial leukemia. Blood. 2020 Oct 22;136(17):1919-1932.