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董芳
研究员,博导
研究方向为造血干细胞生物学调控,在Nature Cell Biology、Blood、Journal of Clinical Investigation等杂志发表多篇SCI论文。主持国家重点研发计划子课题、国家自然科学基金青年B类(优青)和面上项目。曾获2022年度天津市自然科学特等奖。担任中国生理学会血液生理学专委会委员。
研究概述
教育经历
工作经历
主持项目
代表性成果及文章
主要围绕造血干细胞生物学功能调控和再生规律展开研究,尤其利用系列单细胞技术方法揭示稳态和应激条件下造血干细胞的扩增和分化规律。

2014 北京协和医学院              医学博士

2011 兰州大学第二临床医学院 医学硕士

2008 河北医科大学                 医学学士

2024-至今   协和准聘助理教授,研究员

2020-2024  中国医学科学院血液病医院(中国医学科学院血液学研究所)副研究员

2014-2019  中国医学科学院血液病医院(中国医学科学院血液学研究所)科研助理

1. 理化损伤下HSC及微环境的修复研究,国家重点研发计划, 2022YFA1103502,主持,2022/12-2027/11

2. 造血再生与调控,国家自然科学基金青年B类(优秀青年基金)项目,82222004,主持,2023/01-2025/12

3. 新的淋系偏向多能造血祖细胞的鉴定和发育起源,国家自然科学基金面上项目,32671475,主持,2027/01-2030/12

4. 单细胞水平解析小鼠造血干细胞移植后重建动力学规律,国家自然科学基金面上项目,82070112,主持,2021/01-2024/12

5. 2023年天津市杰出青年科学基金

1. Xialin Li, Qitai Yang, Jinglei Zhai, Xiaobing Zhang, Fang Dong*, Hideo Ema*. Tgfbr3 is required for the long-term maintenance of self-renewal potential in murine hematopoietic stem cells. Blood Sci. 2026. Aug 11;8(3):e00307.

2. Jinglei Zhai, Xialin Li, Meiling Yin, Sen Zhang, Xiaoming Liu, Lisha Wang, Nini Wang, Lin Wang, Hideo Ema*, Fang Dong*. Interleukin-12 Supports Self-renewal Division of Mouse Hematopoietic Stem Cells in Polyvinyl Alcohol-Based Culture. Stem Cell Rev Rep. 2026; May 22(4):2001-2014.

3. Fang Dong#, Sen Zhang#, Caiying Zhu#, Zining Yang#, Lisha Wang#, Yao Ma, Jiayi Lu, Xialin Li, Xiaofang Wang, Nini Wang, Shanshan Zhang, Miner Xie, Jinhong Wang, Xiaobing Zhang, Yawei Zheng, Shihui Ma, Hideo Ema, Hui Cheng, Sha Hao, Toshio Suda, Yu Lan, Bing Liu, Ping Zhu, Junren Chen, Tao Cheng. Heterogeneity of high-potency multilineage hematopoietic stem cells and identification of "Super" transplantability. Blood.2025 Jul 31;146(5):546-557.

4. Wen Xing#, Fang Dong#, Yining Liu#, Jiajia Yuan, Chao Chen, Yihan Li, Han Wang, Ming Yao , Ting Chen, Tao Cheng, Sha Hao*, Yuan Zhou*. Deletion of p18INK4c enhances both osteogenesis and hematopoietic supportive capacity of bone marrow mesenchymal stromal cells. Stem Cell Res Ther. 2025 Jul 1;16(1):334.

5. Yaojin Huang, Xiaowei Xie, Mengyao Liu, Yawen Zhang, Junye Yang, Wenling Yang, Yu Hu, Saibing Qi, Yahui Feng, Guojun Liu, Shihong Lu, Xuemei Peng, Jinhui Ye, Shihui Ma, Jiali Sun, Lu Wang, Linping Hu, Lin Wang, Xiaofan Zhu, Hui Cheng, Zimin Sun, Junren Chen, Fang Dong*, Yingchi Zhang*, Tao Cheng*. Restoring mitochondrial function promotes hematopoietic reconstitution from cord blood following cryopreservation-related functional decline. J Clin Invest. 2025 Mar 4;135(9):e183607.

6. Nini Wang#, Shangda Yang#, Yu Li, Fanglin Gou, Yanling Lv, Xiangnan Zhao, Yifei Wang, Chang Xu, Bin Zhou, Fang Dong*, Zhenyu Ju*, Tao Cheng*, Hui Cheng*. p21/Zbtb18 repress the expression of cKit to regulate the self-renewal of hematopoietic stem cells. Protein & Cell. 2024 Nov 1;15(11):840-857.

7. Huimin Sun#, Linjie Wu#, Xueying Zhao#, Yingying Huo, Peiyuan Dong, Aiming Pang, Yawei Zheng, Yiwen Han, Shihui Ma, Erlie Jiang, Fang Dong*, Tao Cheng*, Sha Hao*. Monocytes as an early risk factor for acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Front in Immunol. 2024 Sep 12:15:1433091.

8. Xiaowei Xie#, Fanglin Gou#, Zhaofeng Zheng, Yawen Zhang, Yingchi Zhang, Fang Dong*, Tao Cheng* , Hui Cheng*. Decoding human bone marrow hematopoietic stem and progenitor cells from fetal to birth. iScience. 2024 Jul 3;27(8):110445.

9. Zixian Liu, Jinhong Wang, Yao Ma, Miner Xie, Peng Wu, Sen Zhang, Xiaofang Wang, Fang Dong*, Hui Cheng, Ping Zhu, Mingzhe Han, Hideo Ema*. Early megakaryocyte lineage-committed progenitors in adult mouse bone marrow. Blood Sci. 2024 May 7;6(2):e00187.

10. Sen Zhang#, Yao Ma#, Lisha Wang, Xialin Li, Yan Dong, Jinhong Wang, Tao Cheng, Fang Dong*, Hideo Ema*. Expansion of Quiescent Hematopoietic Stem Cells under Stress and Nonstress Conditions in Mice. Stem Cell Rev Rep. 2022 Oct;18(7):2388-2402.

11. Haitao Bai#, Qingyun Zhang#, Sen Zhang, Jinhong Wang, Bingqing Luo, Yan Dong, Jianzhao Gao, Tao Cheng, Fang Dong*, Hideo Ema*.Multiple cells of origin in common with various types of mouse N-Myc acute leukemia. Leuk Res. 2022 Jun:1;17:106843.

12. Fang Dong#, Sha Hao #, Sen Zhang #, Caiying Zhu#, Hui Cheng#, Zining Yang, Hamey Fiona K, Xiaofang Wang, Ai Gao, FengjiaoWang, Yun Gao, Ji Dong, Chenchen Wang, Jinyong Wang, Yu Lan, Bing Liu, Hideo Ema, Fuchou Tang, Berthold Gottgens*, Ping Zhu* and Tao Cheng*, Differentiation of transplanted hematopoietic stem cells tracked by single cell transcriptomic analysis. Nat Cell Biol, 2020 22(6):630-639.

13. Fang Dong, Hui Cheng*, Hideo Ema*, Tao Cheng*, Probing the fate of transplanted hematopoietic stem cells: is the combinational approach “FIT” for purpose? Sci China Life Sci, 2020;63(11):1755-1758.