周家喜研究员团队长期聚焦生理与病理状态下巨核细胞、血小板的发生机制与功能变化，开发血小板相关再生和诊断系列产品。团队依托人多能干细胞造血分化模型，重点攻关临床输注级血小板规模化制备技术，推动血小板再生产品的临床转化应用。同时运用单细胞深度测序技术，解析生理及病理条件下巨核细胞与血小板的功能变化，挖掘新型功能亚群，指导疾病精准诊疗。

2006-2009美国伊利诺伊大学细胞与发育生物学系 博士后

2004-2006美国思达沃医学研究所 博士后

2004 中国科学院动物所生理学博士

2001  中国农业科学院硕士

1998  华中农业大学动物医学院学士

2024-至今 天津医学健康研究院 副院长

2022-至今 中国医学科学院放射医学研究所 副所长、所长

2020-2022 中国医学科学院血液病医院（中国医学科学院血液学研究所）副所院长

2018-至今 血液与健康全国重点实验室 副主任

2010-至今 中国医学科学院血液病医院（中国医学科学院血液学研究所）研究员

2009-2010 美国伊利诺伊大学细胞与发育生物学系 研究助理

1. 创新药物研发国家科技重大专项，不同功能再生血小板的规模化制备与创新药物研发，2025ZD1803600，2025/12-2028/12

2. 国家自然科学基金重点项目，特殊血小板亚群在血液肿瘤中的作用与机制研究，82430009，2025/01-2029/12

3. 国家杰出青年科学基金，血细胞再生的机制与应用，82125003，2022/1-2026/12

4. 国家自然科学基金面上项目，81870099，MEIS1调控巨核分化和血小板发生的分子机制研究 2019/1-2022/12

5. 国家自然科学基金面上项目，31671541 ，MSX2作为编程因子诱导人多能干细胞分化为间充质干细胞的功能、机理与应用的研究 2017/1-2020/12

6. 国家自然科学基金面上项目，31171431，MSX家族蛋白在人多能干细胞早期分化中功能和作用机理的研究，2012/01-2015/12

1. Meijuan Xia#, Yezi Ma#, Yifei Cai#,Jingjing Zhao#, Yao Zhong, Sibei Guo, Minmin Li, Pei Su, Biao Shen,Huizhen He, Xiaoyuan Chen, Lin Zheng, Le Li, Ziqi Huo, Wen Zhou, Fei Wang, Cuicui Liu,*Hongtao Wang,* and Jiaxi Zhou* A machine learning-based megakaryocyte identification system uncovers resident organs,markers, and functional diversity. Developmental Cell. 2026 Jun 10;61(6):1319-1339.

2. Hongtao Wang^#,Jian He^#,Changlu Xu^#, Xiaoyuan Chen^#,Hua Yang^#, Shujuan Shi, Cuicui Liu, Yang Zeng, Dan Wu, Zhijie Bai, Mengge Wang, Yuqi Wen, Pei Su, Meijuan Xia, Baiming Huang, Chunyu Ma,Lihong Bian, Yu Lan, Tao Cheng, Lihong Shi,* Bing Liu, * Jiaxi Zhou,* Decoding Human Megakaryocyte Development .Cell Stem Cell. 2021 Mar 4;28(3):535-549.

3. Changlu Xu^#, Jian He^#, Hongtao Wang^#, Yingnan Zhang^#, Jing Wu^#, Lu Zhao^#, Yue Li, Jie Gao, Guangfeng Geng, Bingrui Wang, Xiaoyuan Chen, Zhaofeng Zheng, Biao Shen, Yang Zeng, Zhijie Bai, Hua Yang, Shujuan Shi, Fang Dong, Shihui Ma, Erlie Jiang, Tao Cheng, Yu Lan*,Jiaxi Zhou*, Bing Liu*, Lihong Shi*. Single-cell transcriptomic analysis identifies an immune-prone population in erythroid precursors during human ontogenesis. Nature Immunology. 2022 Jul;23(7):1109-1120.

4. Hong Wang#*, Cuicui Liu#, Xiaowei Xie#, Mingming Niu#, Yingrui Wang#, Xuelian Cheng#, Biao Zhang#, Dong Zhang, Mengyao Liu, Rui Sun, Yezi Ma, Shihui Ma, Huijun Wang, Guoqing Zhu, Yang Lu, Baiming Huang, Pei Su, Xiaoyuan Chen, Jingjing Zhao, Hongtao Wang, Long Shen, Lixia Fu, Qianqian Huang, Yang Yang, He Wang, Chunlong Wu, Weigang Ge, Chen Chen, Qianyu Huo, Qingping Wang, Ying Wang, Li Geng, Yan Xie, Yi Xie, Lijun Liu, Jianwei Qi, Huaiyong Chen, Junping Wu, Erlie Jiang, Wentao Jiang, Ximo Wang*, Zhongyang Shen*, Tiannan Guo*, Jiaxi Zhou* , Ping Zhu*, Tao Cheng* Multi-omics blood atlas reveals unique features of immune and platelet responses to SARS-CoV-2 Omicron breakthrough infection. Immunity 2023 Jun 13;56(6):1410-1428

5. Cuicui Liu^#,Dan Wu^#, Meijuan Xia^#, Minmin Li, Zhiqiang Sun, Biao Shen, Yiying Liu,Erlie Jiang, Hongtao Wang, Pei Su, Lihong Shi, Zhijian Xiao, Xiaofan Zhu, Wen Zhou,Qianfei Wang, Xin Gao*, Tao Cheng*,and Jiaxi Zhou* Characterization of Cellular Heterogeneity and an Immune Subpopulation of Human Megakaryocytes. Advanced Science. 2021 Aug;8(15):e2100921.

6. Hongtao Wang^#,, Mengge Wang^#, Yuqi Wen^#, Changlu Xu, Xiaoyuan Chen, Dan Wu, Pei Su, Wen Zhou, Tao Cheng, Lihong Shi*, Jiaxi Zhou* Biphasic Regulation of Mesenchymal Genes Controls Fate Switches During Hematopoietic Differentiation of Human Pluripotent Stem Cells. Advanced Science. 2020 Aug 19;7(20):2001019

7.  Chunmei Kuang # , Meijuan Xia # , Gang An , CuiCui Liu , Cong Hu, Jingyu Zhang , Zhenhao Liu , Bin Meng , Pei Su , Jiliang Xia, Jiaojiao Guo, Yinghong Zhu, Xing Liu , Xuan Wu, Yi Shen , Xiangling Feng , Yanjuan He , Jian Li , Lugui Qiu , Jiaxi Zhou* , Wen Zhou *. Excessive serine from the bone marrow microenvironment impairs megakaryopoiesis and thrombopoiesis in Multiple Myelom. Nature Communications. 2023 Apr 13;14(1):2093.

8. Lin Zheng# , Dan Feng# , Yuting Wu , Wei Liang , Juan Chen , Shijun Ni , Yezi Ma , Pei Su, Cuicui Liu , Sizhou Feng , Wen Zhou, Cha Han , Fei Wang , Erlie Jiang* , Jiaxi Zhou* , Hongtao Wang* Platelets as immune sensors: monitoring immune dynamics and diagnosing disease states across multiple disorders. EbioMedicine. 2026 Mar:125:106174.

9.  Baiming Huang, # Le Li, # Shun Yao, Yue Feng, Runqing Zhang, Wei Liang,Yuting Wu, Pei Su, Fei Wang, Wen Zhou, Hongtao Wang,* Cuicui Liu,* and Jiaxi Zhou* Enhanced regenerative and developmental potential of embryonal and stem cell-derived platelets compared to adult platelets. Cell Reports Medicine. 2025 Aug 19;6(8):102297

10. Qingqing Wu, Leisheng Zhang, Pei Su, Xiaohua Lei, Xin Liu, Hongtao Wang, Lisha Lu, Yang Bai, Tao Xiong, Dong Li, Zhengmao Zhu, Enkui Duan, Erlie Jiang, Sizhou Feng, Mingzhe Han, Yuanfu Xu, Fei Wang, Jiaxi Zhou*. MSX2 mediates entry of human pluripotent stem cells into mesendoderm by simultaneously suppressing SOX2 and activating NODAL signaling. Cell Research. 2015 Dec;25(12):1314-32.

11. Yuqi Wen#, Jingjing Zhao#, Runqing Zhang#, Fan Liu, Xiaoyuan Chen, Dan Wu, Mengge Wang, Cuicui Liu, Pei Su, Panpan Meng, Yiyue Zhang, Xin Gao, Lu Wang, Hongtao Wang*, Jiaxi Zhou*. Identification and characterization of human hematopoietic mesoderm. SCIENCE CHINA Life Sciences 2024 Feb;67(2):320-331