我们研究团队致力于基于质谱的前沿蛋白质组学和代谢组学技术的研发，及最新组学技术在临床血液学和血液系统疾病研究中的应用。研究内容涵盖了从疾病的发生发展到疾病诊疗的全过程，研究对象覆盖了包括血细胞、血小板、细胞外囊泡（外泌体）、及血浆的全景式血液生态系统，研究手段包括了各种最新的组学分析技术和方法。通过将多组学整合研究与本院丰富的大队列临床样本的有机结合，系统性的描绘造血干细胞以及整个造血谱系的蛋白质组图谱；发掘血液系统疾病精准预警、诊断、治疗、预后的生物标志物；开发临床检测技术和试剂盒产品；指导新的免疫治疗、靶向治疗和联合用药策略，推动实验室研究的临床转化。

2017 美国圣犹达儿童研究医院/美国田纳西大学健康医学中心，生物医学科学博士

2011 西南医科大学，医学检验学学士

2017 – 2021 美国圣犹大儿童研究医院，资深蛋白质组学研究员

2016 – 2017 美国圣犹大儿童研究医院，博士后

1. 中国医学科学院创新工程项目子课题，2021年，主持
2. 细胞生态海河实验室“揭榜挂帅”项目子课题，2021年，主持

1.    Elizabeth Stewart#, Justina McEvoy#, Hong Wang#, Xiang Chen#, Victoria Honnell, Monica Ocarz, Brittney Gordon, Jason Dapper, Kaley Blankenship, Yanling Yang, Yuxin Li, Timothy I Shaw, Ji-Hoon Cho, Xusheng Wang, Beisi Xu, Pankaj Gupta, Yiping Fan, Yu Liu, Michael Rusch, Lyra Griffiths, Jongrye Jeon, Burgess B Freeman III, Michael R Clay, Alberto Pappo, John Easton, Sheila Shurtleff, Anang Shelat, Xin Zhou, Kristy Boggs, Heather Mulder, Donald Yergeau, Armita Bahrami, Elaine R Mardis, Richard K Wilson, Jinghui Zhang, Junmin Peng, James R Downing, Michael A Dyer*, St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project. Identification of Therapeutic Targets in Rhabdomyosarcoma Through Integrated Genomic, Epigenomic, and Proteomic Analyses. Cancer Cell. 2018. 34(3):411-426.e19 (影响因子: 31.7)

 2.    Hong Wang#, Alexander K Diaz, Timothy I Shaw, Yuxin Li, Mingming Niu, Ji-Hoon Cho, Barbara S Paugh, Yang Zhang, Jeffrey Sifford, Bing Bai, Zhiping Wu, Haiyan Tan, Suiping Zhou, Laura D Hover, Heather S Tillman, Abbas Shirinifard, Suresh Thiagarajan, Andras Sablauer, Vishwajeeth Pagala, Anthony A High, Xusheng Wang, Chunliang Li, Suzanne J Baker*, Junmin Peng*. Deep multi-omics profiling of brain tumors identifies signaling networks downstream of cancer driver genes. Nature Communications. 2019. 10(1):3718 (年影响因子: 14.9)

 3.    Hong Wang#*, Kaushik Kumar Dey#, Ping-Chung Chen, Yuxin Li, Mingming Niu, Ji-Hoon Cho, Xusheng Wang, Bing Bai, Yun Jiao, Surendhar Reddy Chepyala, Vahram Haroutunian, Bin Zhang, Thomas G. Beach and Junmin Peng*. Integrated analysis of ultra-deep proteomes in cortex, cerebrospinal fluid and serum reveals a mitochondrial signature in Alzheimer’s disease. Molecular Neurodegeneration. 2020.15(1):43 (共同通讯作者；影响因子：14.2)

4.    Beisi Xu#*, Hong Wang#, Shaela Wright, Judith Hyle, Yang Zhang, Ying Shao, Mingming Niu, Yiping Fan, Wojciech Rosikiewicz, Mohamed Nadhir Djekidel, Junmin Peng, Rui Lu, Chunliang Li*. Acute depletion of CTCF rewires genome-wide chromatin accessibility. Genome Biology. 2021.22 (1):1-25 (影响因子: 13.6)

5.    Hong Wang#, Yanling Yang, Yuxin Li, Bing Bai, Xusheng Wang, Haiyan Tan, Tao Liu, Thomas G Beach, Junmin Peng*, Zhiping Wu*. Systematic optimization of long gradient chromatography mass spectrometry for deep analysis of brain proteome. Journal of Proteome Research. 2015 14(2):829-38 (蛋白质组学权威杂志)

6.    Kaushik Kumar Dey#, Hong Wang#, Mingming Niu, Bing Bai, Xusheng Wang, Yuxin Li, Ji-Hoon Cho, Haiyan Tan, Ashutosh Mishra, Anthony A High, Ping-Chung Chen, Zhiping Wu, Thomas G Beach, Junmin Peng*. Deep undepleted human serum proteome profiling toward biomarker discovery for Alzheimer’s disease. Clinical Proteomics. 2019. 16(1):1-12（蛋白质组学权威杂志)

7.    Lixia Fu#, Ziqian Cheng#, Hong Wang *, Mingming Niu*. MS-based blood proteomics: emerging research focus in hematology. Chinese Journal of Cell Biology. 2022.44(1):204-213