1）HSC稳态维持的基因调控网络（功能基因组）以及多组学调控机制；2）HSC发育和稳态维持的微环境新成分鉴定和调控新机制；3）不同类型疾病或应激状态下造血生态变化规律。

2012 中国医学科学院&北京协和医学院内科学博士

2007 浙江大学生物信息学学士

2020-至今   协和准长聘助理教授，研究员

2015-2020  中国医学科学院血液病医院（中国医学科学院血液学研究所）副研究员

2016-2017  以色列魏茨曼科学院访问学者

2013-2015  中国医学科学院血液病医院（中国医学科学院血液学研究所）科研助理

1.    国家自然科学基金青A【原杰青】，82525002，造血调控，2026.01-2030.12

2.    国家自然科学基金重大研究计划重点支持项目，92468206，造血微环境再生修复的多维信息解码，2025.01-2028.12

3.    国家重点研发计划，2020YFE0203000，克隆性造血相关疾病的防控与机制研究，2020.11-2023.08

4.    国家自然科学基金优秀青年科学基金项目，81922002，造血干细胞的生理与病理调控机制，2020.01-2022.12

5.    国家自然科学基金面上项目，81870086，单细胞尺度解析白血病下造血干/祖细胞及其微环境的变化规律及机制，2019.01-2022.12

6.    国家自然科学基金青年科学基金项目，81400077，Egr3调控造血干细胞功能的机制研究，2015.01-2017.12

7.    2019年天津市杰出青年科学基金

8.    2018年首批天津市“青年医学新锐”

9.    2018年第三批天津市“青年拔尖人才支持计划”

10.   中国医学科学院医学与健康科技创新工程，细胞异质性的表观遗传调控机理，2017.01-2020.12，子课题负责人

1.      Duan H, Wang B, Zheng Y, Lv Y, Lu T, Li H, Li P, Li R, Xie X, Yang Z, Sun G, Zhao X, Yang M, He Y, Xu C, Pu S, Zhang L, Shi J, Jiang E*, Cheng T*, Hu Z*, Cheng H*. L-Carnitine Regulates Regeneration of Human Hematopoietic Stem and Progenitor Cells. Blood. 2026

2.      Xu C, Lv X, Yang S, Lv Y, Zheng Y, Wang Y, Hui Y, Sun G, Zhao X, Ma L, Duan H, Zhang L, Pu S, Sun L, Li X, He Y, Fang E, Yang M, Suda T*, Chen Q*, Cheng T*, Cheng H*. Procr⁺ endothelial progenitor cells govern hematopoiesis through fine-tuning mesenchymal stem cell niche signals. Blood. 2026

3.      Pan Z, Deng Y, Huang J, Bian H, Chen Y, Huang A, Jiang C, Wang L, Zhang Z, Lu H, Li S, Yin T, Yu S, Zhu J, Zhao W*, Wang J*, Ji J, Xu Y*, Cheng H*, Chen J*, Hu H*, Hu X*. CD28⁺ CD8⁺ Tem cells with a STAT1-dependent glucocorticoid receptor deficit contribute to steroid-refractory acute GVHD. Blood. 2026

4.      Cao J, Liu Z, Chen X, Lan Z, Liu L, Zhai Y, Wang W, Xue C, Cheng H*, Yao Y*, Cheng T*, Rao S*. Engineered dCas12f1-SAM enables robust transcriptional activation and gain-of-function screening in primary human cells. Nat Commun. 2026

5.      Duan H, Li P, Zhang L, Lv Y, Yang M, He Y, Yang S, Lu S, Cheng T*, Cheng H*. Modulation of nociceptive nerve activity as a novel therapeutic strategy in acute myeloid leukemia. Fundamental Res. 2026

6.      Li Y, Cao J, Tong J, Tang P, Chen H, Sun G, Yang Z, Zhang X, Dong F, Yang S, Gao J, Zhao X, Ma J, Wang D, Zhang L, Wang L*, Cheng T*, Cheng H*, Shi L*. Leukemia-expanded splenic CD81⁺ erythroblasts potentiate disease progression in mice by reshaping leukemic cell metabolism. J Clin Invest. 2025

7.      Lv H, Wang C, Liu Z, Quan M, Li K, Gou F, Shi X, Liu Q, Yu Y, Zhu P, Cheng H*, Cheng T*, Ai D*. Suppression of the Prostaglandin I2-Type 1 Interferon Axis Induces Extramedullary Hematopoiesis to Promote Cardiac Repair After Myocardial Infarction. Circulation. 2025

8.      Gao R, Chen K, Wang Y, Guo R, Zhang X, Wu P, Wang W, Huang Q, Xie X, Yang S, Lv Y, Ren Q, Liu F, Chen S, Ma F, Cheng T*, Cheng H*. FHL2 deficiency aggravates Candida albicans infection through decreased myelopoiesis. Sci China Life Sci. 2025

9.      Pu S, Cheng T*, Cheng H*. Advances in RNA editing in hematopoiesis and associated malignancies. Blood. 2025

10.    Wang N, Yang S, Li Y, Gou F, Lv Y, Zhao X, Wang Y, Xu C, Zhou B, Dong F*, Ju Z*, Cheng T*, Cheng H*. p21/Zbtb18 repress the expression of cKit to regulate the self-renewal of hematopoietic stem cells. Protein & Cell. 2024

11.    Zheng Z, Yang S, Gou F, Tang C, Zhang Z, Gu Q, Sun G, Jiang P, Wang N, Zhao X, Kang J, He Y, Yang M, Lu T, Lu S, Qian P*, Zhu P*, Cheng H*, Cheng T*. The ATF4-RPS19BP1 axis modulates ribosome biogenesis to promote erythropoiesis. Blood. 2024

12.    Li M, Sun G, Zhao J, Pu S, Lv Y, Wang Y, Li Y, Zhao X, Wang Y*, Yang S*, Cheng T*, Cheng H*. Small extracellular vesicles derived from acute myeloid leukemia cells promote leukemogenesis by transferring miR-221-3p. Haematologica. 2024

13.    Li J, Liu J, Li Y, Chen L, Cheng H*, Li Y*, Cheng T*, Wang Q*, Zhou B*. Differentiation route determines the functional outputs of adult megakaryopoiesis. Immunity, 2024

14.    Xie X, Gou F, Zheng Z, Zhang Y, Zhang Y, Dong F*, Cheng T*, Cheng H*. Decoding human bone marrow hematopoietic stem and progenitor cells from fetal to birth. iScience.

15.    Lin Y, Gu Q, Lu S, Pan Z, Yang Z, Li Y, Yang S, Lv Y, Zheng Z, Sun G, Gou F, Xu C, Zhao X, Wang F, Wang C, Yuan S, Xie X, Cao Y, Liu Y, Gu W*, Cheng T*, Cheng H*, and Hu X*. Ruxolitinib improves hematopoietic regeneration by restoring mesenchymal stromal cell function in acute graft-versus-host disease.  J Clin Invest. 2023

16.    Zhang B, Li Y, Zhang J, Wang Y, Liang C, Lu T, Zhang C, Liu L, Qin Y, He J, Zhao X, Yu J, Hao J, Yang J, Li J, Yao Z, Ma S*, Cheng H*, Cheng T*, Shi L*. ADAR1 links R-loop homeostasis to ATR activation in replication stress response. Nucleic Acids Res. 2023

17.    Zheng Z, He H, Tang X, Zhang H, Gou F, Yang H, Cao J, Shi S, Yang Z, Sun G, Xie X, Zeng Y, Wen A, Lan Y, Zhou J, Liu B*, Zhou B*, Cheng T*, Cheng H*. Uncovering the emergence of HSCs in the human fetal bone marrow by single cell RNA-seq analysis. Cell Stem Cell. 2022

18.    Sun G, Gu Q, Zheng J*, Cheng H*, Cheng T*. Emerging roles of extracellular vesicles in normal and malignant hematopoiesis. J Clin Invest. 2022

19.    Yang S, Sun G, Wu P, Chen C, Kuang Y, Liu L, Zheng Z, He Y, Gu Q, Lu T, Zhu C, Wang F, Gou F, Yang Z, Zhao X, Yuan S, Yang L, Lu S, Li Y, Lv X, Dong F, Ma Y, Yu J, Ng L, Shi L, Liu J*, Shi L*, Cheng T*, Cheng H*. WDR82-binding long non-coding RNA lncEry controls mouse erythroid differentiation and maturation. J Exp Med. 2022

20.    Wang T, Xia C, Weng Q, Wang K, Dong Y, Hao S, Dong F, Liu X, Liu L, Geng Y, Guan Y, Du J, Cheng T, Cheng H*, Wang J*. Loss of Nupr1 promotes engraftment by tuning the quiescence threshold of hematopoietic stem cell repository via regulating p53-checkpoint pathway. Haematologica. 2022

21.    Wang F, He J, Liu S, Gao A, Yang L, Sun G, Ding W, Li C, Wang F, Wang X, Zhu P, Hao S, Ma Y*, Cheng H*, Yu J*, Cheng T*. A comprehensive RNA editome reveals that edited Azin1 partners with DDX1 to enable hematopoietic stem cell differentiation. Blood. 2021

22.    Huang D, Sun G, Hao X, He X, Zheng Z, Chen C, Yu Z, Xie L, Ma S, Liu L, Zhou B, Cheng H*, Zheng J*, and Cheng T*. ANGPTL2-containing small extracellular vesicles from vascular endothelial cells accelerate leukemia progression. J Clin Invest. 2021

23.    Ma S, Sun G, Yang S, Ju Z*, Cheng T*, Cheng H*. Effects of telomere length on leukemogenesis. Sci China Life Sci. 2025

24.    Zhang C, Xu Z, Yang S, Sun G, Jia L, Zheng Z, Gu Q, Tao W*, Cheng T*, Li C* and Cheng H*. tagHi-C reveals 3D chromatin architecture dynamics during hematopoiesis. Cell Rep. 2020

25.    Wang Y, Lu T, Sun G, Zheng Y, Yang S, Zhang H, Hao S, Liu Y, Ma S, Zhang H, Ru Y, Gao S, Yen K*, Cheng H*, Cheng T*. Targeting of apoptosis gene loci by reprogramming factors leads to selective eradication of leukemia cells. Nature Commun. 2019

26.    Gao A, Gong Y, Zhu C, Yang W, Li Q, Zhao M, Ma S, Li J, Hao S*, Cheng H*, Cheng T*. Bone marrow endothelial cell-derived interleukin-4 contributes to thrombocytopenia in acute myeloid leukemia. Haematologica. 2019

27.    Gong Y, Zhao M, Yang W, Gao A, Yin X, Hu L, Wang X, Xu J, Hao S, Cheng T*, Cheng H*. Megakaryocyte-derived excessive transforming growth factor β1 inhibits proliferation of normal hematopoietic stem cells in acute myeloid leukemia. Exp Hematol. 2018