造血干细胞发育受到多种因素的精密调控，调控失衡将导致血液发育缺陷或相关疾病。深入系统地研究造血干细胞（HSC）发育中的关键因子及作用机制，对完善调控网络和治疗相关疾病具有重要意义。我们致力于揭示造血干细胞产生的分子调控机制，从细胞内源因子（遗传与表观遗传）和微环境角度，应用遗传学分析、高通量测序以及谱系示踪等技术，系统解析胚胎期造血干细胞发育的调控机制，包括：表观遗传修饰DNA甲基化及m⁶A甲基化影响造血干细胞命运决定（Dev, 2022; Nature, 2017）；发现造血干细胞异质性起源（Cell Res, 2023）；揭示RNA结合蛋白Csde1调控造血干细胞产生过程的机制（Dev, 2023）；在造血干细胞分化过程中，Rac2调控T淋巴前体细胞迁移以及分化（Stem Cell Reports, 2020; J Immunol, 2020）；发现表观遗传修饰DNA甲基化和RNA甲基化调控胚胎早期发育（EMBO J, 2017; Mol Cell, 2019）。

2009-2013   中国科学院动物研究所   博士

2007-2009   北京科技大学           硕士

2003-2007   江苏大学               学士

2019–2019 中国医学科学院血液学研究所  研究员

2016-2019  中国科学院动物研究所        副研究员

2013-2016  中国科学院动物研究所        博士后

1、国家自然科学基金优秀青年基金，2023/1-2025/12

2、国家重点研发计划青年科学家项目，2019/9-2024/8

3、国家自然科学基金面上项目，2022/01-2025/12

4、天津市杰出青年科学基金，2021/10-2025/9

5、国家自然科学基金面上项目，2018/01-2021/12

6、中国科协“青年人才托举工程”项目，2016-2018年度

通讯/共同作者文章

1.    Ying Li#, Can Li#, Mengyao Liu, Shicheng Liu, Feng Liu*, Lu Wang*. The RNA-binding protein CSDE1 promotes hematopoietic stem and progenitor cell generation via translational control of Wnt signaling. Development, 2023 Nov 1; 150(21): dev201890.

2.    Xia J#, Liu M#, Zhu C, Liu S, Ai L, Ma D, Zhu P, Wang Lu*, Liu Feng*. Activation of lineage competence in hemogenic endothelium precedes the formation of hematopoietic stem cell heterogeneity. Cell Res. 2023 Jun;33(6):448-463.

3.    Li Y#, Tang C#, Liu F, Liu F, Zhu P*, Wang L*. DNA methylation safeguards endothelial-to-hematopoietic transition by repression of Notch signaling. Development. 2022 May 15;149(10):dev200390. doi: 10.1242/dev.200390.

4.    Lv P^#, Ma D^#, Gao S^#, Zhang Y, Bae YK, Liang G, Gao S, Choi JH, Kim CH, Wang L*, Liu F*. Generation of foxn1/Casper Mutant Zebrafish for Allograft and Xenograft of Normal and Malignant Cells. Stem Cell Reports. 2020 Sep 8;15(3):749-760.

5.    Lu X, Zhang Y, Liu F*, and Wang L*. Rac2 Regulates the Migration of T Lymphoid Progenitors to the Thymus During Zebrafish Embryogenesis. J Immunol. 2020, 204(9):2447-2454.

6.    Liu ZB, Tu HQ, Kang YS, Xue YY, Ma DY, Zhao CT, Li HY, Wang L*, Liu F*. Primary cilia regulate hematopoietic stem and progenitor cell specification through Notch signaling in zebrafish. Nature Commun. 2019, 10(1):1839.

7.    Liu F, Liu F*, Wang L*. COVID-19 and cardiovascular diseases. J Mol Cell Biol. 2021. 13(3):161-7. 

第一/共一作者文章

8.    Yang Y^#, Wang L^#, Han X^#, Yang WL^#, Zhang M^#, Ma HL, Sun BF, Li A, Xia J, Chen J, Heng J, Wu B, Chen YS, Xu JW, Yang X, Yao H, Sun J, Lyu C, Wang HL, Huang Y, Sun YP, Zhao YL, Meng A, Ma J*, Liu F* and Yang YG*. (2019) RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay. Mol Cell. 2019, 75(6):1188-1202.

9.    Wang L, Liu ZB, Lin H, Ma DY, Tao QH, Liu F*. Epigenetic regulation of left-right asymmetry by DNA methylation. EMBO J. 2017, 36(20):2987-97

10.  Zhang CX^#, Chen YS^#, Sun BF^#, Wang L^#, Yang Y^#, Ma DY, Lv JH, Heng J, Ding YY, Xue YY, Lu XY, Xiao W, Yang YG*, Liu F*. m6A modulates haematopoietic stem and progenitor cell specification. Nature. 2017, 549(7671):273-76

11.  Lv JH^#, Wang L^#, Gao Y, Ding YQ, Liu F*. 5-hydroxytryptamine synthesized in the aorta-gonad-mesonephros regulates hematopoietic stem and progenitor cell survival. J Exp Med. 2017, 214(2):529-545

12.  Liu TH^#, Tang YJ^#, Huang Y^#, Wang L^#, Guo XL, Mi JQ, Liu LG, Zhu H, Zhang Y, Chen L, Liu X, Zhang LH, Ye QJ, Li BS, Tang JY, Ford A, Enver T, Liu F*, Chen GQ*, Hong DL*. Expression of the fetal hematopoiesis regulator FEV indicates leukemias of prenatal origin. Leukemia. 2017, 31(5):1079-1086

13.  Wang L^#, Zhang CX^#,, Liu F*. Molecular regulation of hematopoietic stem cell development. Scientia Sinica Vitae. 2016, 46(1);16-24 

14.  He QP^#, Zhang CX^#, Wang L^#, Zhang PP, Ma DY, Lv JH, Liu F*. Inflammatory signaling regulates hematopoietic stem and progenitor cell emergence in vertebrates. Blood. 2015, 125(7):1098-106

15.  Ping XL^#, Sun BF^#, Wang L^#, Xiao W^#, Yang X, Wang WJ, Samir A, Shi Y, Lv Y, Chen YS, Zhao X, Li A, Yang Y, Ujwal D, Lou XM, Liu X, Huang J, Yuan WP, Zhu XF, Cheng T, Zhao YL, Wang XQ, Danielsen JMR, Liu F*, Yang YG*. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. Cell Res. 2014, 24(2):177-89

16.  Wang L^#, Liu TH^#, Xu LJ^#, Gao Y, Wei YL, Duan C, Chen GQ, Lin S, Patient R, Zhang B, Hong DL, Liu F*. Fev regulates hematopoietic stem cell development via ERK signaling. Blood. 2013, 122(3):367-75

17.  Ma DY^#, Wang L^#, Wang SF^#, Gao Y, Wei YL, Liu F*. Foxn1 maintains thymic epithelial cells to support T-cell development via mcm2 in zebrafish. PNAS. 2012, 109(51):21040-5

18.  Wang L, Zhang PP, Wei YL, Gao Y, Patient R, Liu F*. A blood flow-dependent klf2a-NO signaling cascade is required for stabilization of hematopoietic stem cell programming in zebrafish embryos. Blood. 2011, 118(15):4102-10